S100A10 downregulation inhibits the phagocytosis of Cryptococcus neoformans by murine brain microvascular endothelial cells

Cryptococcus neoformans invades the central nerve system through endocytosis by the vascular endothelia. S100A10 interacts with Ca 2+ channel proteins in the vascular endothelia and regulates the filamentous actin network. We hypothesized that S100A10 was involved in the pathogenesis of cryptococcos...

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Veröffentlicht in:	Microbial pathogenesis 2011-09, Vol.51 (3), p.96-100
Hauptverfasser:	Chen, Yuchong, Chen, Jianghan, Wen, Hai, Gao, Pinghui, Wang, Jun, Zheng, Zhizhong, Gu, Julin
Format:	Artikel
Sprache:	eng
Schlagworte:	actin Animals Annexin A2 - antagonists & inhibitors Annexin A2 - immunology Biological and medical sciences brain Brain - immunology Brain - microbiology calcium Calcium - analysis calcium channels cryptococcosis Cryptococcus neoformans Cryptococcus neoformans - immunology Cryptococcus neoformans - pathogenicity Cytosol - chemistry endothelial cells Endothelial Cells - immunology Endothelial Cells - microbiology Fundamental and applied biological sciences. Psychology Gene Knockdown Techniques Gene Silencing Mice Microbiology Miscellaneous Murine brain microvascular endothelial cell (MBMEC) Mycology nerve tissue pathogenesis Phagocytosis RNA interference RNA, Small Interfering - metabolism S100 Proteins - antagonists & inhibitors S100 Proteins - immunology S100A10 small interfering RNA
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Zusammenfassung:	Cryptococcus neoformans invades the central nerve system through endocytosis by the vascular endothelia. S100A10 interacts with Ca 2+ channel proteins in the vascular endothelia and regulates the filamentous actin network. We hypothesized that S100A10 was involved in the pathogenesis of cryptococcosis and sought to investigate here the effect on the phagocytosis and growth of C. neoformans of S100A10 downregulation by small interfering RNA in murine brain microvascular endothelial cell (MBMECs). We found that S100A10 downregulation significantly reduced the intracellular Ca 2+ concentration ( P
ISSN:	0882-4010 1096-1208
DOI:	10.1016/j.micpath.2011.05.003