The association of the TP53 polymorphisms Pro72Arg and C(−594)CC with diabetic polyneuropathy in Russian Muscovites with type 1 diabetes mellitus

The allele and genotype frequency distributions of the Pro72Arg and C(-594)CC polymorphisms of the TP53 gene were studied in type 1 diabetes mellitus (T1DM) patients, ethnic Russians from Moscow, with a T1DM record of no more than 5 years and diabetic polyneuropathy (DPN) or a T1DM record of more than 10 years but without DPN. The Pro72Arg polymorphism was associated with DPN, a higher risk of DPN being determined by allele Arg (OR = 1.96, CI 1.32-2.90) and genotype Arg/Arg (OR = 2.14, CI 1.23-3.73). Allele Pro was associated with a lower risk of DPN (OR = 0.51, CI 0.34-0.76). No association with DPN was observed for the C(-594)CC polymorphism.[PUBLICATION ABSTRACT]