Use of Interferon-Gamma Release Assay for Latent Tuberculosis Infection Screening in Older Adults Exposed to Tuberculosis in a Nursing Home
OBJECTIVES: To assess the additive value of a newly marketed interferon‐gamma release assay, QuantiFERON‐TB Gold In‐Tube (QFT‐GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home. DESIGN:...
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| Veröffentlicht in: | Journal of the American Geriatrics Society (JAGS) 2011-05, Vol.59 (5), p.858-862 |
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| container_title | Journal of the American Geriatrics Society (JAGS) |
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| creator | Katsenos, Stamatis Nikolopoulou, Melita Gartzonika, Constantina Manda-Stachouli, Carmen Gogali, Athena Grypaiou, Christodoula Mavridis, Anestis Constantopoulos, Stavros H. Daskalopoulos, George |
| description | OBJECTIVES: To assess the additive value of a newly marketed interferon‐gamma release assay, QuantiFERON‐TB Gold In‐Tube (QFT‐GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home.
DESIGN: Contact tracing included clinical examination, chest radiography, TST, and QFT‐GIT in TST‐negative people (TST |
| doi_str_mv | 10.1111/j.1532-5415.2011.03367.x |
| format | Article |
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DESIGN: Contact tracing included clinical examination, chest radiography, TST, and QFT‐GIT in TST‐negative people (TST<5 mm).
SETTING: A private nursing home.
PARTICIPANTS: Seventy‐seven individuals (63 elderly residents, 14 young employees) who had been exposed to an active TB case in a private nursing home.
MEASUREMENTS: Comparison of TST and QFT‐GIT in older adults who have been exposed to TB.
RESULTS: For the TST, the positive response rate was 31.7% (n=20) of elderly residents and 43% (n=6) of staff. Positive QFT‐GIT results were obtained in seven (16.3%) elderly residents with negative TST, six of whom were aged 80 and older. QFT‐GIT increased the percentage of possible LTBI in this group from 31.7% to 42.9%.
CONCLUSION: QFT‐GIT has a significant additive value to single TST for detecting LTBI in institutionalized older adults, identifying infected subjects anergic to the TST.</description><identifier>ISSN: 0002-8614</identifier><identifier>EISSN: 1532-5415</identifier><identifier>DOI: 10.1111/j.1532-5415.2011.03367.x</identifier><identifier>PMID: 21517785</identifier><identifier>CODEN: JAGSAF</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>Adult ; Aged, 80 and over ; Anergy ; Bacterial diseases ; Biological and medical sciences ; Chest ; Contact tracing ; Cross Infection - diagnosis ; elderly ; Female ; gamma -Interferon ; General aspects ; Geriatrics ; Gold ; Human bacterial diseases ; Human exposure ; Humans ; Infection ; Infectious diseases ; Interferon-gamma ; Latent Tuberculosis - diagnosis ; latent tuberculosis infection ; Male ; Mass Screening - methods ; Medical sciences ; Medical screening ; Mycobacterium ; Nursing ; Nursing Homes ; Older people ; Prevention and actions ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; QuantiFERON-TB Gold In-Tube ; Radiography ; Skin tests ; Tuberculin ; tuberculin skin test ; Tuberculin Test - methods ; Tuberculosis ; Tuberculosis and atypical mycobacterial infections</subject><ispartof>Journal of the American Geriatrics Society (JAGS), 2011-05, Vol.59 (5), p.858-862</ispartof><rights>2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society</rights><rights>2015 INIST-CNRS</rights><rights>2011, Copyright the Authors. Journal compilation © 2011, The American Geriatrics Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4467-516ed334ee8a8bd3a8923e8e1ef2f7c75b79cbe86ed85bad2510d5be2b5fdc9e3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fj.1532-5415.2011.03367.x$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fj.1532-5415.2011.03367.x$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,782,786,1419,27931,27932,45581,45582</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=24239779$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21517785$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Katsenos, Stamatis</creatorcontrib><creatorcontrib>Nikolopoulou, Melita</creatorcontrib><creatorcontrib>Gartzonika, Constantina</creatorcontrib><creatorcontrib>Manda-Stachouli, Carmen</creatorcontrib><creatorcontrib>Gogali, Athena</creatorcontrib><creatorcontrib>Grypaiou, Christodoula</creatorcontrib><creatorcontrib>Mavridis, Anestis</creatorcontrib><creatorcontrib>Constantopoulos, Stavros H.</creatorcontrib><creatorcontrib>Daskalopoulos, George</creatorcontrib><title>Use of Interferon-Gamma Release Assay for Latent Tuberculosis Infection Screening in Older Adults Exposed to Tuberculosis in a Nursing Home</title><title>Journal of the American Geriatrics Society (JAGS)</title><addtitle>J Am Geriatr Soc</addtitle><description>OBJECTIVES: To assess the additive value of a newly marketed interferon‐gamma release assay, QuantiFERON‐TB Gold In‐Tube (QFT‐GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home.
DESIGN: Contact tracing included clinical examination, chest radiography, TST, and QFT‐GIT in TST‐negative people (TST<5 mm).
SETTING: A private nursing home.
PARTICIPANTS: Seventy‐seven individuals (63 elderly residents, 14 young employees) who had been exposed to an active TB case in a private nursing home.
MEASUREMENTS: Comparison of TST and QFT‐GIT in older adults who have been exposed to TB.
RESULTS: For the TST, the positive response rate was 31.7% (n=20) of elderly residents and 43% (n=6) of staff. Positive QFT‐GIT results were obtained in seven (16.3%) elderly residents with negative TST, six of whom were aged 80 and older. QFT‐GIT increased the percentage of possible LTBI in this group from 31.7% to 42.9%.
CONCLUSION: QFT‐GIT has a significant additive value to single TST for detecting LTBI in institutionalized older adults, identifying infected subjects anergic to the TST.</description><subject>Adult</subject><subject>Aged, 80 and over</subject><subject>Anergy</subject><subject>Bacterial diseases</subject><subject>Biological and medical sciences</subject><subject>Chest</subject><subject>Contact tracing</subject><subject>Cross Infection - diagnosis</subject><subject>elderly</subject><subject>Female</subject><subject>gamma -Interferon</subject><subject>General aspects</subject><subject>Geriatrics</subject><subject>Gold</subject><subject>Human bacterial diseases</subject><subject>Human exposure</subject><subject>Humans</subject><subject>Infection</subject><subject>Infectious diseases</subject><subject>Interferon-gamma</subject><subject>Latent Tuberculosis - diagnosis</subject><subject>latent tuberculosis infection</subject><subject>Male</subject><subject>Mass Screening - methods</subject><subject>Medical sciences</subject><subject>Medical screening</subject><subject>Mycobacterium</subject><subject>Nursing</subject><subject>Nursing Homes</subject><subject>Older people</subject><subject>Prevention and actions</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>QuantiFERON-TB Gold In-Tube</subject><subject>Radiography</subject><subject>Skin tests</subject><subject>Tuberculin</subject><subject>tuberculin skin test</subject><subject>Tuberculin Test - methods</subject><subject>Tuberculosis</subject><subject>Tuberculosis and atypical mycobacterial infections</subject><issn>0002-8614</issn><issn>1532-5415</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkt1u0zAYhi0EYmVwC8hCQhwl-CeOnQMOyn66QdmAbeLQcpwvKCWJi51o7TVw0zi0FMEJPrGl93k-y_KLEKYkpXG9XqVUcJaIjIqUEUpTwnku080DNDsED9GMEMISldPsCD0JYUUIZUSpx-iIUUGlVGKGftwFwK7Gl_0Avgbv-mRhus7gz9CCidk8BLPFtfN4aQboB3w7luDt2LrQhKjVYIfG9fjGeoC-6b_ipsfXbQUez6uxHQI-26xdgAoP7m83cgZfjT5M0oXr4Cl6VJs2wLP9fozuzs9uTy6S5fXi8mS-TGyW5TIRNIeK8wxAGVVW3KiCcVBAoWa1tFKUsrAlqEgpUZqKCUoqUQIrRV3ZAvgxerWbu_bu-whh0F0TLLSt6cGNQRdEUlEUcer_SJVLzhjNiki--IdcudH38RkRyjOaSyEi9HwPjWUHlV77pjN-q39_RwRe7gETrGlrb3rbhD9cxngh5XTbmx1337SwPeSU6KkeeqWnFuipBXqqh_5VD73R7xY30yn6yc5vwgCbg2_8Nx1TKfSXq4U-_fSen4q3H_UH_hPQ-b2Q</recordid><startdate>201105</startdate><enddate>201105</enddate><creator>Katsenos, Stamatis</creator><creator>Nikolopoulou, Melita</creator><creator>Gartzonika, Constantina</creator><creator>Manda-Stachouli, Carmen</creator><creator>Gogali, Athena</creator><creator>Grypaiou, Christodoula</creator><creator>Mavridis, Anestis</creator><creator>Constantopoulos, Stavros H.</creator><creator>Daskalopoulos, George</creator><general>Blackwell Publishing Inc</general><general>Wiley-Blackwell</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201105</creationdate><title>Use of Interferon-Gamma Release Assay for Latent Tuberculosis Infection Screening in Older Adults Exposed to Tuberculosis in a Nursing Home</title><author>Katsenos, Stamatis ; Nikolopoulou, Melita ; Gartzonika, Constantina ; Manda-Stachouli, Carmen ; Gogali, Athena ; Grypaiou, Christodoula ; Mavridis, Anestis ; Constantopoulos, Stavros H. ; Daskalopoulos, George</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4467-516ed334ee8a8bd3a8923e8e1ef2f7c75b79cbe86ed85bad2510d5be2b5fdc9e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Aged, 80 and over</topic><topic>Anergy</topic><topic>Bacterial diseases</topic><topic>Biological and medical sciences</topic><topic>Chest</topic><topic>Contact tracing</topic><topic>Cross Infection - diagnosis</topic><topic>elderly</topic><topic>Female</topic><topic>gamma -Interferon</topic><topic>General aspects</topic><topic>Geriatrics</topic><topic>Gold</topic><topic>Human bacterial diseases</topic><topic>Human exposure</topic><topic>Humans</topic><topic>Infection</topic><topic>Infectious diseases</topic><topic>Interferon-gamma</topic><topic>Latent Tuberculosis - diagnosis</topic><topic>latent tuberculosis infection</topic><topic>Male</topic><topic>Mass Screening - methods</topic><topic>Medical sciences</topic><topic>Medical screening</topic><topic>Mycobacterium</topic><topic>Nursing</topic><topic>Nursing Homes</topic><topic>Older people</topic><topic>Prevention and actions</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>QuantiFERON-TB Gold In-Tube</topic><topic>Radiography</topic><topic>Skin tests</topic><topic>Tuberculin</topic><topic>tuberculin skin test</topic><topic>Tuberculin Test - methods</topic><topic>Tuberculosis</topic><topic>Tuberculosis and atypical mycobacterial infections</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Katsenos, Stamatis</creatorcontrib><creatorcontrib>Nikolopoulou, Melita</creatorcontrib><creatorcontrib>Gartzonika, Constantina</creatorcontrib><creatorcontrib>Manda-Stachouli, Carmen</creatorcontrib><creatorcontrib>Gogali, Athena</creatorcontrib><creatorcontrib>Grypaiou, Christodoula</creatorcontrib><creatorcontrib>Mavridis, Anestis</creatorcontrib><creatorcontrib>Constantopoulos, Stavros H.</creatorcontrib><creatorcontrib>Daskalopoulos, George</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Katsenos, Stamatis</au><au>Nikolopoulou, Melita</au><au>Gartzonika, Constantina</au><au>Manda-Stachouli, Carmen</au><au>Gogali, Athena</au><au>Grypaiou, Christodoula</au><au>Mavridis, Anestis</au><au>Constantopoulos, Stavros H.</au><au>Daskalopoulos, George</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Interferon-Gamma Release Assay for Latent Tuberculosis Infection Screening in Older Adults Exposed to Tuberculosis in a Nursing Home</atitle><jtitle>Journal of the American Geriatrics Society (JAGS)</jtitle><addtitle>J Am Geriatr Soc</addtitle><date>2011-05</date><risdate>2011</risdate><volume>59</volume><issue>5</issue><spage>858</spage><epage>862</epage><pages>858-862</pages><issn>0002-8614</issn><eissn>1532-5415</eissn><coden>JAGSAF</coden><abstract>OBJECTIVES: To assess the additive value of a newly marketed interferon‐gamma release assay, QuantiFERON‐TB Gold In‐Tube (QFT‐GIT), to a single tuberculin skin test (TST) for the detection of latent tuberculosis infection (LTBI) in older adults who have been exposed to TB in a nursing home.
DESIGN: Contact tracing included clinical examination, chest radiography, TST, and QFT‐GIT in TST‐negative people (TST<5 mm).
SETTING: A private nursing home.
PARTICIPANTS: Seventy‐seven individuals (63 elderly residents, 14 young employees) who had been exposed to an active TB case in a private nursing home.
MEASUREMENTS: Comparison of TST and QFT‐GIT in older adults who have been exposed to TB.
RESULTS: For the TST, the positive response rate was 31.7% (n=20) of elderly residents and 43% (n=6) of staff. Positive QFT‐GIT results were obtained in seven (16.3%) elderly residents with negative TST, six of whom were aged 80 and older. QFT‐GIT increased the percentage of possible LTBI in this group from 31.7% to 42.9%.
CONCLUSION: QFT‐GIT has a significant additive value to single TST for detecting LTBI in institutionalized older adults, identifying infected subjects anergic to the TST.</abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>21517785</pmid><doi>10.1111/j.1532-5415.2011.03367.x</doi><tpages>5</tpages></addata></record> |
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| ispartof | Journal of the American Geriatrics Society (JAGS), 2011-05, Vol.59 (5), p.858-862 |
| issn | 0002-8614 1532-5415 |
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| source | MEDLINE; Access via Wiley Online Library |
| subjects | Adult Aged, 80 and over Anergy Bacterial diseases Biological and medical sciences Chest Contact tracing Cross Infection - diagnosis elderly Female gamma -Interferon General aspects Geriatrics Gold Human bacterial diseases Human exposure Humans Infection Infectious diseases Interferon-gamma Latent Tuberculosis - diagnosis latent tuberculosis infection Male Mass Screening - methods Medical sciences Medical screening Mycobacterium Nursing Nursing Homes Older people Prevention and actions Public health. Hygiene Public health. Hygiene-occupational medicine QuantiFERON-TB Gold In-Tube Radiography Skin tests Tuberculin tuberculin skin test Tuberculin Test - methods Tuberculosis Tuberculosis and atypical mycobacterial infections |
| title | Use of Interferon-Gamma Release Assay for Latent Tuberculosis Infection Screening in Older Adults Exposed to Tuberculosis in a Nursing Home |
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