Role of the Brain Dopaminergic and Opioid System in the Regulation of “Child's” (Maternal Bonding) Behavior of Newborn Albino Rats

Administration of D₂ receptor antagonist clebopride in a dose not affecting locomotor activity was followed by a decrease in maternal bonding behavior of 10-day-old and 15-day-old albino rat pups. D₁ receptor antagonist SCH23390 had a stimulatory effect only on the behavior of 10-day-old newborns. O...

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Veröffentlicht in:	Bulletin of experimental biology and medicine 2011, Vol.150 (3), p.281-285
Hauptverfasser:	Stovolosov, I. S, Dubynin, V. A, Kamensky, A. A
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Newborn Behavior, Animal - drug effects Benzamides - pharmacology Benzazepines - pharmacology Biomedical and Life Sciences Biomedicine Brain - metabolism Catecholamines Cell Biology Dopamine Antagonists - pharmacology D₁ receptor antagonists and D₂ receptor antagonists Endorphins - pharmacology Internal Medicine Laboratory Medicine Laws, regulations and rules maternal bonding behavior of newborns Object Attachment Pathology Peptide Fragments - pharmacology Rats β-casomorphins
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Zusammenfassung:	Administration of D₂ receptor antagonist clebopride in a dose not affecting locomotor activity was followed by a decrease in maternal bonding behavior of 10-day-old and 15-day-old albino rat pups. D₁ receptor antagonist SCH23390 had a stimulatory effect only on the behavior of 10-day-old newborns. Opioid peptide β-casomorphin-7 abolished the effect of clebopride in rat pups of the older age group.
ISSN:	0007-4888 1573-8221
DOI:	10.1007/s10517-011-1123-4