Phellinstatin, a new inhibitor of enoyl-ACP reductase produced by the medicinal fungus Phellinus linteus

A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 M and also show...

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Veröffentlicht in:	Bioorganic & medicinal chemistry letters 2011-03, Vol.21 (6), p.1716-1718
Hauptverfasser:	Cho, Jun-Young, Kwon, Yun-Ju, Sohn, Mi-Jin, Seok, Soon-Ja, Kim, Won-Gon
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibacterial antibacterial properties Biological and medical sciences Catechols - pharmacology chemistry culture media Enoyl-(Acyl-Carrier-Protein) Reductase (NADH) Enoyl-ACP reductase Enzyme Inhibitors - pharmacology Fungi - enzymology General pharmacology Hispidin Inhibitor Inhibitory Concentration 50 Magnetic Resonance Spectroscopy Medical sciences medicinal fungi Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Phellinus linteus Pyrones - pharmacology spectral analysis Spectrometry, Mass, Electrospray Ionization Spectrophotometry, Infrared Staphylococcus aureus
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Zusammenfassung:	A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 M and also showed antibacterial activity against S. aureus and MRSA. A new trimeric hispidin derivative, phellinstatin, was isolated from a culture broth of the medicinal fungus Phellinus linteus and its structure was established by various spectral analysis. Phellinstatin strongly inhibited Staphylococcus aureus enoyl-ACP reductase with an IC 50 of 6 μM and also showed antibacterial activity against S. aureus and MRSA.
ISSN:	0960-894X 1464-3405
DOI:	10.1016/j.bmcl.2011.01.080