Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human ?-Defensins 2 and 3

Interaction between the Candida albicans High-Osmolarity Glycerol (HOG) Pathway and the Response to Human ?-Defensins 2 and 3

Human ?-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response t...

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Veröffentlicht in:Eukaryotic cell 2011-02, Vol.10 (2), p.272-275
Hauptverfasser: Argimon, Silvia, Fanning, Saranna, Blankenship, Jill R, Mitchell, Aaron P
Format: Artikel
Sprache:eng
Schlagworte:
Candida albicans
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Zusammenfassung:Human ?-defensins 2 and 3 are small cationic peptides with antimicrobial activity against the fungal pathogen Candida albicans. We found that hog1 and pbs2 mutants were hypersensitive to treatment with these peptides, pointing to a role of the high-osmolarity glycerol (HOG) pathway in the response to defensin-induced cell injury.
ISSN:1535-9786
DOI:10.1128/EC.00133-10