Effects of Low Molecular Weight Sulfated Galactan Fragments From Botryocladia Occidentalis on the Pharmacological and Enzymatic Activity of Spla2 From Crotalus Durissus Cascavella

Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the condi...

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Veröffentlicht in:	Protein Journal 2010-11, Vol.29 (8), p.567-571
Hauptverfasser:	Toyama, M. H., Toyama, D. O., Torres, V. M., Pontes, G. C., Farias, W. R. L., Melo, F. R., Oliveira, S. C. B., Fagundes, F. H. R., Diz Filho, E. B. S., Cavada, B. S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Algae Analysis Animal Anatomy Animals Biochemistry Bioorganic Chemistry Botryocladia occidentalis Brief Communication Chemistry Chemistry and Materials Science Crotalid Venoms - chemistry Crotalid Venoms - metabolism Crotalid Venoms - pharmacology Crotalus - metabolism Crotalus durissus cascavella Drug Interactions Edema Edema - chemically induced Edema - drug therapy Enzymatic activity Enzymes Galactans - chemistry Galactans - isolation & purification Galactans - pharmacology Histology Kinetics Male Mast Cells - drug effects Molecular weight Morphology Neurotoxicity Organic Chemistry Pharmacology Phospholipases A2, Secretory - chemistry Phospholipases A2, Secretory - metabolism Phospholipases A2, Secretory - toxicity Rats Rats, Wistar Rattlesnakes Rhodophyta - chemistry Skin - drug effects Skin - pathology Structure-Activity Relationship Sulfates Sulfates - chemistry Toxicity Venom
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Beschreibung
Zusammenfassung:	Low molecular weight fragments of sulfated galactans (Boc-5 and Boc-10) from the red algae Botryocladia occidentalis significantly inhibited Crotalus durissus cascavella sPLA2 enzymatic activity. Equimolar ratios of sPLA2 to Boc-5 or Boc-10 resulted in allosteric inhibition of sPLA2. Under the conditions tested, we observed that both Boc-5 and Boc-10 strongly decreased edema, myonecrosis, and neurotoxicity induced by native sPLA2.
ISSN:	1572-3887 1573-4943 1875-8355
DOI:	10.1007/s10930-010-9294-9