The impact of smoking on outcomes among patients undergoing hematopoietic SCT for the treatment of acute leukemia

A paucity of research exists examining the potential impact of tobacco use on cancer treatment outcomes, especially among patients treated with hematopoietic SCT (HSCT). A retrospective cohort study design was used to examine the impact of smoking on duration of hospitalization and overall survival...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2011-02, Vol.46 (2), p.285-290
Hauptverfasser:	Ehlers, S L, Gastineau, D A, Patten, C A, Decker, P A, Rausch, S M, Cerhan, J R, Hogan, W J, Ebbert, J O, Porrata, L F
Format:	Artikel
Sprache:	eng
Schlagworte:	692/699/67/1990/283 692/700/565/545/576/1955 Acute leukemia Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction Care and treatment Cell Biology Cohort Studies Development and progression Drug therapy Female Health aspects Hematology Hematopoietic Stem Cell Transplantation Hematopoietic stem cells Humans Internal Medicine Length of Stay Leukemia Leukemia, Lymphocytic, Chronic, B-Cell - mortality Leukemia, Lymphocytic, Chronic, B-Cell - surgery Leukemia, Myeloid, Acute - mortality Leukemia, Myeloid, Acute - surgery Male Medical sciences Medicine Medicine & Public Health Middle Aged original-article Patient outcomes Patients Public Health Pulmonary functions Respiratory function Retrospective Studies Risk factors Smoking Smoking - adverse effects Social aspects Stem cell transplantation Stem Cells Survival Tobacco Tobacco, tobacco smoking Toxicology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Treatment Outcome
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Zusammenfassung:	A paucity of research exists examining the potential impact of tobacco use on cancer treatment outcomes, especially among patients treated with hematopoietic SCT (HSCT). A retrospective cohort study design was used to examine the impact of smoking on duration of hospitalization and overall survival among 148 consecutive patients undergoing HSCT for treatment of acute leukemia from 1999 to 2005. Of the 148 patients, 15% reported current smoking, 30% former smoking, and 55% never used tobacco. Patients were followed for a median 3.5 years (interquartile range=2.1–5.5). Compared to no history of smoking, current smoking was associated with worse pre-HSCT pulmonary function tests ( P
ISSN:	0268-3369 1476-5365
DOI:	10.1038/bmt.2010.113