Catalytic Hydroacylation as an Approach to Homoaldol Products

Catalytic Hydroacylation as an Approach to Homoaldol Products

A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products in 50–98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to bo...

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Veröffentlicht in:Organic letters 2011-12, Vol.13 (23), p.6216-6219
Hauptverfasser: Murphy, Stephen K, Petrone, David A, Coulter, Matthew M, Dong, Vy M
Format: Artikel
Sprache:eng
Schlagworte:
Alcohols - chemical synthesis
Alcohols - chemistry
Aldehydes - chemical synthesis
Aldehydes - chemistry
Catalysis
Combinatorial Chemistry Techniques
Styrenes - chemistry
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Zusammenfassung:A method has been developed for the intermolecular hydroacylation of homoallyl alcohols with salicylaldehydes to furnish homoaldol products in 50–98% yields. The method also applies to the hydroacylation of 2-hydroxystyrenes. This work highlights the use of hydroacylation as a unified approach to both aldol and homoaldol products.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202663p