Role of RANK, RANKL, OPG, and CXCR4 Tissue Markers in Predicting Bone Metastases in Breast Cancer Patients

Micro-Abstract This is a retrospective study on 40 breast cancer patients, of which 20 have bone metastases, 10 have visceral metastases, and 10 have no evidence of disease, aimed at evaluating the role of CXCR4 and the RANK/RANKL/OPG system to predict bone metastases. CXCR4 expression, alone or in...

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Veröffentlicht in:	Clinical breast cancer 2011-12, Vol.11 (6), p.369-375
Hauptverfasser:	Ibrahim, Toni, Sacanna, Emanuele, Gaudio, Michele, Mercatali, Laura, Scarpi, Emanuela, Zoli, Wainer, Serra, Patrizia, Ricci, Rossana, Serra, Luigi, Kang, Yibin, Amadori, Dino
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biomarkers, Tumor - metabolism Bone metastases Bone Neoplasms - metabolism Bone Neoplasms - secondary Breast cancer Breast Neoplasms - metabolism Breast Neoplasms - pathology Case-Control Studies CXCR4 Female Hematology, Oncology and Palliative Medicine Humans Middle Aged Neoplasm Metastasis Obstetrics and Gynecology OPG Osteoprotegerin - metabolism Predictive Value of Tests RANK Ligand - metabolism RANK/RANKL Receptors, CXCR4 - metabolism Retrospective Studies
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Zusammenfassung:	Micro-Abstract This is a retrospective study on 40 breast cancer patients, of which 20 have bone metastases, 10 have visceral metastases, and 10 have no evidence of disease, aimed at evaluating the role of CXCR4 and the RANK/RANKL/OPG system to predict bone metastases. CXCR4 expression, alone or in combination with RANK, identified patients destined to relapse to bone.
ISSN:	1526-8209 1938-0666
DOI:	10.1016/j.clbc.2011.05.001