Synthesis of Biaryls via AlCl3 Catalyzed Domino Reaction Involving Cyclization, Dehydration, and Oxidation

Synthesis of Biaryls via AlCl3 Catalyzed Domino Reaction Involving Cyclization, Dehydration, and Oxidation

A new chemical access has been developed to synthesize biaryls from substituted acetophenones, phenylacetones, dihydrochalcone, and 2-acetylnaphthalene in reasonably good yields at room temperature via a domino reaction sequence of AlCl3 catalyzed cyclization, dehydration, and then oxidation.

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Bibliographische Detailangaben
Veröffentlicht in:Organic letters 2011-12, Vol.13 (23), p.6140-6143
Hauptverfasser: Narender, Tadigoppula, Sarkar, Satinath, Rajendar, Kandikonda, Tiwari, Sriniwas
Format: Artikel
Sprache:eng
Schlagworte:
Acetone - analogs & derivatives
Acetone - chemistry
Acetophenones - chemistry
Aluminum Compounds - chemistry
Biphenyl Compounds - chemical synthesis
Biphenyl Compounds - chemistry
Catalysis
Chalcones - chemistry
Chlorides - chemistry
Combinatorial Chemistry Techniques
Cyclization
Dehydration
Molecular Structure
Naphthalenes - chemistry
Oxidation-Reduction
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Beschreibung
Zusammenfassung:A new chemical access has been developed to synthesize biaryls from substituted acetophenones, phenylacetones, dihydrochalcone, and 2-acetylnaphthalene in reasonably good yields at room temperature via a domino reaction sequence of AlCl3 catalyzed cyclization, dehydration, and then oxidation.
ISSN:1523-7060
1523-7052
DOI:10.1021/ol202638m