Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer
Purpose This study was designed to examine the aggressive features of BRAF -positive papillary thyroid cancer (PTC) and association with age. Methods We compared the clinicopathologic parameters and BRAF V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy fr...
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| Veröffentlicht in: | Annals of surgical oncology 2011-12, Vol.18 (13), p.3566-3571 |
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| creator | Howell, Gina M. Carty, Sally E. Armstrong, Michaele J. LeBeau, Shane O. Hodak, Steven P. Coyne, Christopher Stang, Michael T. McCoy, Kelly L. Nikiforova, Marina N. Nikiforov, Yuri E. Yip, Linwah |
| description | Purpose
This study was designed to examine the aggressive features of
BRAF
-positive papillary thyroid cancer (PTC) and association with age.
Methods
We compared the clinicopathologic parameters and
BRAF
V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age |
| doi_str_mv | 10.1245/s10434-011-1781-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_905964978</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1753471595</sourcerecordid><originalsourceid>FETCH-LOGICAL-c403t-cf79c43ae3c2bc9b1d0dca2065859429b21adbd459f442febb13f72ed17a0ab93</originalsourceid><addsrcrecordid>eNp9kU9O3DAUh62qqPwpB2CDrG6ARcDPseN4OYyAVgKBEEXqynLsFwjKJIOdCHEEbsGmF-lROAkeDW0lpHZly_78vef3I2QL2D5wIQ8iMJGLjAFkoErI5AeyBjKdiKKEj2nPijLTvJCrZD3GO8ZA5Ux-IqscpBaK5WukPeyHW3p4OTmm1wVjR_RsHOzQ9B21nafnrcdAJzdId1-efhby1_MPtCHuURuQTmLsXWMH9PShSZJLdGMI2A30ws6btrXhkV7dPoa-8XRqO4fhM1mpbRtx823dIN-Pj66mX7PT85Nv08lp5gTLh8zVSjuRW8wdr5yuwDPvLGeFLFPbXFccrK-8kLoWgtdYVZDXiqMHZZmtdL5BdpbeeejvR4yDmTXRYWqpw36MRjOpC6FVmcjd_5Kg0jhVmpZM6Jd36F0_hi79Y-FTUpe6SBAsIRf6GAPWZh6aWZqEAWYWmZllZiZlZhaZmYV4-008VjP0f178DikBfAnEdNXdYPhb-d_WVxjSoNk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>905759896</pqid></control><display><type>article</type><title>Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Howell, Gina M. ; Carty, Sally E. ; Armstrong, Michaele J. ; LeBeau, Shane O. ; Hodak, Steven P. ; Coyne, Christopher ; Stang, Michael T. ; McCoy, Kelly L. ; Nikiforova, Marina N. ; Nikiforov, Yuri E. ; Yip, Linwah</creator><creatorcontrib>Howell, Gina M. ; Carty, Sally E. ; Armstrong, Michaele J. ; LeBeau, Shane O. ; Hodak, Steven P. ; Coyne, Christopher ; Stang, Michael T. ; McCoy, Kelly L. ; Nikiforova, Marina N. ; Nikiforov, Yuri E. ; Yip, Linwah</creatorcontrib><description>Purpose
This study was designed to examine the aggressive features of
BRAF
-positive papillary thyroid cancer (PTC) and association with age.
Methods
We compared the clinicopathologic parameters and
BRAF
V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age <65 years) PTC patients.
Results
Younger and elderly PTC patients had similar incidences of
BRAF
-positive tumors (41% vs. 38%;
p
= 0.67). The elderly cohort was more likely to have smaller tumors (mean 1.6 vs. 2.1 cm;
p
= 0.001), present with advanced TNM stage (36% vs. 19%;
p
= 0.008), and have persistent/recurrent disease (10% vs. 1%;
p
= 0.006).
BRAF
-positive status was associated with PTC that were tall cell variant (
p
< 0.001), had extrathyroidal extension (
p
< 0.001), lymph node involvement (
p
= 0.008), advanced (III/IV) TNM stage (
p
< 0.001), and disease recurrence (
p
< 0.001). Except for lymph node involvement, the association between aggressive histology characteristics at presentation and
BRAF
-positive PTC also was observed within the age-defined cohorts. In short-term follow-up (mean, 18 months), persistent/recurrent PTC was much more likely to occur in patients who were both
BRAF
-positive and elderly (22%).
Conclusions
BRAF
mutations are equally present in younger and older patients. Aggressive histology characteristics at presentation are associated with
BRAF
-positive PTC, irrespective of age. However, the well-established association of
BRAF
with recurrence is limited to older (age ≥65 years) patients.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-011-1781-5</identifier><identifier>PMID: 21594703</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Age Factors ; Aged ; Aged, 80 and over ; Carcinoma, Papillary - genetics ; DNA, Neoplasm - genetics ; Endocrine Tumors ; Female ; Follow-Up Studies ; Humans ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Neoplasm Recurrence, Local - genetics ; Neoplasm Recurrence, Local - pathology ; Neoplasm Recurrence, Local - surgery ; Oncology ; Point Mutation - genetics ; Polymerase Chain Reaction ; Prognosis ; Proto-Oncogene Proteins B-raf - genetics ; Retrospective Studies ; Risk Factors ; Surgery ; Surgical Oncology ; Survival Rate ; Thyroid Neoplasms - genetics ; Young Adult</subject><ispartof>Annals of surgical oncology, 2011-12, Vol.18 (13), p.3566-3571</ispartof><rights>Society of Surgical Oncology 2011</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c403t-cf79c43ae3c2bc9b1d0dca2065859429b21adbd459f442febb13f72ed17a0ab93</citedby><cites>FETCH-LOGICAL-c403t-cf79c43ae3c2bc9b1d0dca2065859429b21adbd459f442febb13f72ed17a0ab93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-011-1781-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-011-1781-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,777,781,27905,27906,41469,42538,51300</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21594703$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Howell, Gina M.</creatorcontrib><creatorcontrib>Carty, Sally E.</creatorcontrib><creatorcontrib>Armstrong, Michaele J.</creatorcontrib><creatorcontrib>LeBeau, Shane O.</creatorcontrib><creatorcontrib>Hodak, Steven P.</creatorcontrib><creatorcontrib>Coyne, Christopher</creatorcontrib><creatorcontrib>Stang, Michael T.</creatorcontrib><creatorcontrib>McCoy, Kelly L.</creatorcontrib><creatorcontrib>Nikiforova, Marina N.</creatorcontrib><creatorcontrib>Nikiforov, Yuri E.</creatorcontrib><creatorcontrib>Yip, Linwah</creatorcontrib><title>Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Purpose
This study was designed to examine the aggressive features of
BRAF
-positive papillary thyroid cancer (PTC) and association with age.
Methods
We compared the clinicopathologic parameters and
BRAF
V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age <65 years) PTC patients.
Results
Younger and elderly PTC patients had similar incidences of
BRAF
-positive tumors (41% vs. 38%;
p
= 0.67). The elderly cohort was more likely to have smaller tumors (mean 1.6 vs. 2.1 cm;
p
= 0.001), present with advanced TNM stage (36% vs. 19%;
p
= 0.008), and have persistent/recurrent disease (10% vs. 1%;
p
= 0.006).
BRAF
-positive status was associated with PTC that were tall cell variant (
p
< 0.001), had extrathyroidal extension (
p
< 0.001), lymph node involvement (
p
= 0.008), advanced (III/IV) TNM stage (
p
< 0.001), and disease recurrence (
p
< 0.001). Except for lymph node involvement, the association between aggressive histology characteristics at presentation and
BRAF
-positive PTC also was observed within the age-defined cohorts. In short-term follow-up (mean, 18 months), persistent/recurrent PTC was much more likely to occur in patients who were both
BRAF
-positive and elderly (22%).
Conclusions
BRAF
mutations are equally present in younger and older patients. Aggressive histology characteristics at presentation are associated with
BRAF
-positive PTC, irrespective of age. However, the well-established association of
BRAF
with recurrence is limited to older (age ≥65 years) patients.</description><subject>Adult</subject><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Carcinoma, Papillary - genetics</subject><subject>DNA, Neoplasm - genetics</subject><subject>Endocrine Tumors</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Neoplasm Recurrence, Local - genetics</subject><subject>Neoplasm Recurrence, Local - pathology</subject><subject>Neoplasm Recurrence, Local - surgery</subject><subject>Oncology</subject><subject>Point Mutation - genetics</subject><subject>Polymerase Chain Reaction</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><subject>Survival Rate</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Young Adult</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNp9kU9O3DAUh62qqPwpB2CDrG6ARcDPseN4OYyAVgKBEEXqynLsFwjKJIOdCHEEbsGmF-lROAkeDW0lpHZly_78vef3I2QL2D5wIQ8iMJGLjAFkoErI5AeyBjKdiKKEj2nPijLTvJCrZD3GO8ZA5Ux-IqscpBaK5WukPeyHW3p4OTmm1wVjR_RsHOzQ9B21nafnrcdAJzdId1-efhby1_MPtCHuURuQTmLsXWMH9PShSZJLdGMI2A30ws6btrXhkV7dPoa-8XRqO4fhM1mpbRtx823dIN-Pj66mX7PT85Nv08lp5gTLh8zVSjuRW8wdr5yuwDPvLGeFLFPbXFccrK-8kLoWgtdYVZDXiqMHZZmtdL5BdpbeeejvR4yDmTXRYWqpw36MRjOpC6FVmcjd_5Kg0jhVmpZM6Jd36F0_hi79Y-FTUpe6SBAsIRf6GAPWZh6aWZqEAWYWmZllZiZlZhaZmYV4-008VjP0f178DikBfAnEdNXdYPhb-d_WVxjSoNk</recordid><startdate>20111201</startdate><enddate>20111201</enddate><creator>Howell, Gina M.</creator><creator>Carty, Sally E.</creator><creator>Armstrong, Michaele J.</creator><creator>LeBeau, Shane O.</creator><creator>Hodak, Steven P.</creator><creator>Coyne, Christopher</creator><creator>Stang, Michael T.</creator><creator>McCoy, Kelly L.</creator><creator>Nikiforova, Marina N.</creator><creator>Nikiforov, Yuri E.</creator><creator>Yip, Linwah</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>20111201</creationdate><title>Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer</title><author>Howell, Gina M. ; Carty, Sally E. ; Armstrong, Michaele J. ; LeBeau, Shane O. ; Hodak, Steven P. ; Coyne, Christopher ; Stang, Michael T. ; McCoy, Kelly L. ; Nikiforova, Marina N. ; Nikiforov, Yuri E. ; Yip, Linwah</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c403t-cf79c43ae3c2bc9b1d0dca2065859429b21adbd459f442febb13f72ed17a0ab93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Adult</topic><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Carcinoma, Papillary - genetics</topic><topic>DNA, Neoplasm - genetics</topic><topic>Endocrine Tumors</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Neoplasm Recurrence, Local - genetics</topic><topic>Neoplasm Recurrence, Local - pathology</topic><topic>Neoplasm Recurrence, Local - surgery</topic><topic>Oncology</topic><topic>Point Mutation - genetics</topic><topic>Polymerase Chain Reaction</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Surgical Oncology</topic><topic>Survival Rate</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Howell, Gina M.</creatorcontrib><creatorcontrib>Carty, Sally E.</creatorcontrib><creatorcontrib>Armstrong, Michaele J.</creatorcontrib><creatorcontrib>LeBeau, Shane O.</creatorcontrib><creatorcontrib>Hodak, Steven P.</creatorcontrib><creatorcontrib>Coyne, Christopher</creatorcontrib><creatorcontrib>Stang, Michael T.</creatorcontrib><creatorcontrib>McCoy, Kelly L.</creatorcontrib><creatorcontrib>Nikiforova, Marina N.</creatorcontrib><creatorcontrib>Nikiforov, Yuri E.</creatorcontrib><creatorcontrib>Yip, Linwah</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Annals of surgical oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Howell, Gina M.</au><au>Carty, Sally E.</au><au>Armstrong, Michaele J.</au><au>LeBeau, Shane O.</au><au>Hodak, Steven P.</au><au>Coyne, Christopher</au><au>Stang, Michael T.</au><au>McCoy, Kelly L.</au><au>Nikiforova, Marina N.</au><au>Nikiforov, Yuri E.</au><au>Yip, Linwah</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer</atitle><jtitle>Annals of surgical oncology</jtitle><stitle>Ann Surg Oncol</stitle><addtitle>Ann Surg Oncol</addtitle><date>2011-12-01</date><risdate>2011</risdate><volume>18</volume><issue>13</issue><spage>3566</spage><epage>3571</epage><pages>3566-3571</pages><issn>1068-9265</issn><eissn>1534-4681</eissn><abstract>Purpose
This study was designed to examine the aggressive features of
BRAF
-positive papillary thyroid cancer (PTC) and association with age.
Methods
We compared the clinicopathologic parameters and
BRAF
V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age <65 years) PTC patients.
Results
Younger and elderly PTC patients had similar incidences of
BRAF
-positive tumors (41% vs. 38%;
p
= 0.67). The elderly cohort was more likely to have smaller tumors (mean 1.6 vs. 2.1 cm;
p
= 0.001), present with advanced TNM stage (36% vs. 19%;
p
= 0.008), and have persistent/recurrent disease (10% vs. 1%;
p
= 0.006).
BRAF
-positive status was associated with PTC that were tall cell variant (
p
< 0.001), had extrathyroidal extension (
p
< 0.001), lymph node involvement (
p
= 0.008), advanced (III/IV) TNM stage (
p
< 0.001), and disease recurrence (
p
< 0.001). Except for lymph node involvement, the association between aggressive histology characteristics at presentation and
BRAF
-positive PTC also was observed within the age-defined cohorts. In short-term follow-up (mean, 18 months), persistent/recurrent PTC was much more likely to occur in patients who were both
BRAF
-positive and elderly (22%).
Conclusions
BRAF
mutations are equally present in younger and older patients. Aggressive histology characteristics at presentation are associated with
BRAF
-positive PTC, irrespective of age. However, the well-established association of
BRAF
with recurrence is limited to older (age ≥65 years) patients.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>21594703</pmid><doi>10.1245/s10434-011-1781-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1068-9265 |
| ispartof | Annals of surgical oncology, 2011-12, Vol.18 (13), p.3566-3571 |
| issn | 1068-9265 1534-4681 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_905964978 |
| source | MEDLINE; SpringerLink Journals - AutoHoldings |
| subjects | Adult Age Factors Aged Aged, 80 and over Carcinoma, Papillary - genetics DNA, Neoplasm - genetics Endocrine Tumors Female Follow-Up Studies Humans Male Medicine Medicine & Public Health Middle Aged Neoplasm Recurrence, Local - genetics Neoplasm Recurrence, Local - pathology Neoplasm Recurrence, Local - surgery Oncology Point Mutation - genetics Polymerase Chain Reaction Prognosis Proto-Oncogene Proteins B-raf - genetics Retrospective Studies Risk Factors Surgery Surgical Oncology Survival Rate Thyroid Neoplasms - genetics Young Adult |
| title | Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer |
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