Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer

Both BRAF V600E Mutation and Older Age (≥65 Years) are Associated with Recurrent Papillary Thyroid Cancer

Purpose This study was designed to examine the aggressive features of BRAF -positive papillary thyroid cancer (PTC) and association with age. Methods We compared the clinicopathologic parameters and BRAF V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy fr...

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Veröffentlicht in:Annals of surgical oncology 2011-12, Vol.18 (13), p.3566-3571
Hauptverfasser: Howell, Gina M., Carty, Sally E., Armstrong, Michaele J., LeBeau, Shane O., Hodak, Steven P., Coyne, Christopher, Stang, Michael T., McCoy, Kelly L., Nikiforova, Marina N., Nikiforov, Yuri E., Yip, Linwah
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age Factors
Aged
Aged, 80 and over
Carcinoma, Papillary - genetics
DNA, Neoplasm - genetics
Endocrine Tumors
Female
Follow-Up Studies
Humans
Male
Medicine
Medicine & Public Health
Middle Aged
Neoplasm Recurrence, Local - genetics
Neoplasm Recurrence, Local - pathology
Neoplasm Recurrence, Local - surgery
Oncology
Point Mutation - genetics
Polymerase Chain Reaction
Prognosis
Proto-Oncogene Proteins B-raf - genetics
Retrospective Studies
Risk Factors
Surgery
Surgical Oncology
Survival Rate
Thyroid Neoplasms - genetics
Young Adult
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Zusammenfassung:Purpose This study was designed to examine the aggressive features of BRAF -positive papillary thyroid cancer (PTC) and association with age. Methods We compared the clinicopathologic parameters and BRAF V600E mutation status of 121 elderly (age ≥65 years) PTC patients who underwent thyroidectomy from January 2007 to December 2009 to a consecutive cohort of 98 younger (age
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-011-1781-5