Helical tomotherapy for resected malignant pleural mesothelioma: Dosimetric evaluation and toxicity

Abstract This study evaluated adjuvant helical tomotherapy after extrapleural pneumonectomy ± neo-adjuvant chemotherapy in 24 patients with malignant pleural mesothelioma. Toxicity was judged acceptable despite 2 cases (8%) of suspected grade 5 pneumonitis. With a mean follow-up of 7 months, 5 patie...

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Veröffentlicht in:	Radiotherapy and oncology 2011-11, Vol.101 (2), p.303-306
Hauptverfasser:	Giraud, Philippe, Sylvestre, Alma, Zefkili, Sofia, Lisbona, Albert, Bonnette, Pierre, Le Pimpec Barthes, Françoise, Paris, Edouard, Perigaud, Christian, Savignoni, Alexia, Mahé, Marc-André
Format:	Artikel
Sprache:	eng
Schlagworte:	Female France - epidemiology Hematology, Oncology and Palliative Medicine Humans Male Mean lung dose Mesothelioma Mesothelioma - drug therapy Mesothelioma - pathology Mesothelioma - radiotherapy Mesothelioma - surgery Middle Aged Neoadjuvant Therapy Neoplasm Staging Pleural Neoplasms - drug therapy Pleural Neoplasms - pathology Pleural Neoplasms - radiotherapy Pleural Neoplasms - surgery Pneumonectomy Pneumonitis Radiation Pneumonitis - epidemiology Radiotherapy Radiotherapy - methods Radiotherapy Dosage Retrospective Studies Tomotherapy Treatment Failure
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Zusammenfassung:	Abstract This study evaluated adjuvant helical tomotherapy after extrapleural pneumonectomy ± neo-adjuvant chemotherapy in 24 patients with malignant pleural mesothelioma. Toxicity was judged acceptable despite 2 cases (8%) of suspected grade 5 pneumonitis. With a mean follow-up of 7 months, 5 patients had distant and 2 local and distant failure.
ISSN:	0167-8140 1879-0887
DOI:	10.1016/j.radonc.2011.06.040