Type 2 diabetes mellitus and testosterone: a meta‐analysis study

Summary Several studies suggest that type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. Despite the well‐known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. The aim of the present study was to analyse systematically the r...

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Veröffentlicht in:International journal of andrology 2011-12, Vol.34 (6pt1), p.528-540
Hauptverfasser: Corona, G., Monami, M., Rastrelli, G., Aversa, A., Sforza, A., Lenzi, A., Forti, G., Mannucci, E., Maggi, M.
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Sprache:eng
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Zusammenfassung:Summary Several studies suggest that type 2 diabetes mellitus (T2DM) is often associated with male hypogonadism. Despite the well‐known link, the role of testosterone replacement therapy (TRT) in T2DM has not been completely clarified. The aim of the present study was to analyse systematically the relationship between androgen levels and T2DM by reviewing and meta‐analysing available prospective and cross‐sectional studies. In addition, a specific meta‐analysis on the metabolic effects of TRT in available randomized clinical trials (RCTs) was performed. An extensive Medline search was performed including the following words: ‘testosterone’, ‘type 2 diabetes mellitus’ and ‘males’. Of 742 retrieved articles, 37 were included in the study. In particular 28, 5 and 3 were cross‐sectional, longitudinal and interventional studies, respectively. A further unpublished RCT was retrieved from http://www.clinicaltrials.gov. T2DM patients showed significantly lower testosterone plasma levels in comparison with non‐diabetic individuals. Similar results were obtained when T2DM subjects with and without erectile dysfunction were analysed separately. Meta‐regression analysis demonstrated that ageing reduced, while obesity increased, these differences. However, in a multiple regression model, after adjusting for age and body mass index (BMI), T2DM was still associated with lower total testosterone (TT) levels (adjusted r = −0.568; p 
ISSN:0105-6263
1365-2605
DOI:10.1111/j.1365-2605.2010.01117.x