A fluorescent probe for GM1 gangliosidosis related I super(2)-galactosidase: N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-ga l actitol
N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-ga lact itol, a strong competitive inhibitor of I super(2)-galactosidase, enhances residual I super(2)-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant I super(2...
Gespeichert in:
Veröffentlicht in: | Bioorganic & medicinal chemistry letters 2011-11, Vol.21 (22), p.6872-6875 |
---|---|
Hauptverfasser: | , , , , , , , , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
Zusammenfassung: | N-(Dansylamino)hexylaminocarbonylpentyl-1,5-dideoxy-1,5-imino-d-ga lact itol, a strong competitive inhibitor of I super(2)-galactosidase, enhances residual I super(2)-galactosidase activities in fibroblasts and serves as lead en route to diagnostic compounds for tracking the fate of mutant I super(2)-gal as well as aberrant GM1 gangliosides by live cell imaging. |
---|---|
ISSN: | 0960-894X |
DOI: | 10.1016/j.bmcl.2011.09.012 |