Synthesis and antifungal and antibacterial activity of hexahydronicotine derivatives

Synthesis and antifungal and antibacterial activity of hexahydronicotine derivatives

Acylation of hexahydronicotine with anhydrides of dicarboxylic acids yielded amido acids. Reaction of amido acids with amines, ethanol, and hydrazine produced derivatives. Studies of these compounds showed them to have antifungal and antibacterial activity.

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Veröffentlicht in:Pharmaceutical chemistry journal 2008-04, Vol.42 (4), p.180-182, Article 180
Hauptverfasser: Kagarlitskii, A. D., Krichevskii, L. A., Astaf’eva, Z. M., Akhmetova, S. B., Seidakhmetova, R. B., Drab, A. I.
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Acylation
amines
Antibacterial activity
Antifungal agents
Ethanol
Hydrazine
Medicine
Organic Chemistry
Pharmacology/Toxicology
Pharmacy
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Zusammenfassung:Acylation of hexahydronicotine with anhydrides of dicarboxylic acids yielded amido acids. Reaction of amido acids with amines, ethanol, and hydrazine produced derivatives. Studies of these compounds showed them to have antifungal and antibacterial activity.
ISSN:0091-150X
1573-9031
DOI:10.1007/s11094-008-0098-6