Successful switch to tenofovir after suboptimal response to entecavir in an immunocompromised patient with chronic hepatitis B and without genotypic hepatitis B virus resistance

We report a case of an immunocompromised patient affected by chronic hepatitis B virus (HBV) with high basal HBV viremia (>8 log 10 IU/ml) who failed an entecavir regimen, despite the absence of primary or secondary drug resistance mutations. The patient achieved sustained virological success (s...

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Veröffentlicht in:	Infection 2011-08, Vol.39 (4), p.367-370
Hauptverfasser:	Sarrecchia, C., Svicher, V., Volpi, A., Salpini, R., Ceccarelli, L., Sordillo, P., Bertoli, A., Perno, C. F., Andreoni, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenine - analogs & derivatives Adenine - therapeutic use Adult Alanine Transaminase - blood Antiviral Agents - therapeutic use Bone Marrow - immunology Bone Marrow - physiopathology Case Report DNA, Viral - blood Drug resistance Drug Therapy, Combination Family Medicine Female General Practice Guanine - analogs & derivatives Guanine - therapeutic use Hepatitis Hepatitis B Hepatitis B virus Hepatitis B virus - genetics Hepatitis B, Chronic - drug therapy Hepatitis B, Chronic - virology Humans Immunocompromised Host Infectious Diseases Internal Medicine Italy Medicine Medicine & Public Health Organophosphonates - therapeutic use Tenofovir Treatment Outcome Viremia - drug therapy Viremia - virology
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Zusammenfassung:	We report a case of an immunocompromised patient affected by chronic hepatitis B virus (HBV) with high basal HBV viremia (>8 log 10 IU/ml) who failed an entecavir regimen, despite the absence of primary or secondary drug resistance mutations. The patient achieved sustained virological success (serum HBV DNA
ISSN:	0300-8126 1439-0973
DOI:	10.1007/s15010-011-0127-3