Synthesis and antifungal activity of some carbamate-containing azaheterocycles

A series of carbamate-containing derivatives of 1,2-and 1,4-oxazine, isoxazoline, isoxazole, benzimidazole-3-oxide, and indole were obtained by [3 + 2]-cycloaddition and ring-closure reactions. The antifungal activity of the synthesized compounds was studied in vitro against Microsporum canis, Trich...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Pharmaceutical chemistry journal 2011, Vol.44 (10), p.536-539
Hauptverfasser:	Velikorodov, A. V, Kovalev, V. B, Degtyarev, O. V, Titova, O. L
Format:	Artikel
Sprache:	eng
Schlagworte:	Antifungal activity Antifungal agents Benzimidazole Candida albicans carbamate-containing azaheterocycles Carbamates cycloaddition and ring-closure reactions Indole Medicine Microsporum canis Organic Chemistry Pharmacology/Toxicology Pharmacy Salts Sodium Trichophyton rubrum
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	A series of carbamate-containing derivatives of 1,2-and 1,4-oxazine, isoxazoline, isoxazole, benzimidazole-3-oxide, and indole were obtained by [3 + 2]-cycloaddition and ring-closure reactions. The antifungal activity of the synthesized compounds was studied in vitro against Microsporum canis, Trichophyton rubrum, and Candida albicans. Among the tested compounds, the maximum antifungal activity was observed for tautomeric 5(6)-alkoxycarboxamido derivatives of 2-aryl-1-hydroxybenzimidazole-3-oxide sodium salts and 1,2-oxazines.
ISSN:	0091-150X 1573-9031
DOI:	10.1007/s11094-011-0513-2