Dual roles of CagA protein in Helicobacter pylori-induced chronic gastritis in mice

Dual roles of CagA protein in Helicobacter pylori-induced chronic gastritis in mice

Cytotoxin-associated gene A (CagA) acts directly on gastric epithelial cells. However, the roles of CagA in host adaptive immunity against Helicobacter pylori (H. pylori) infection are not fully understood. In this study, to investigate the roles of CagA in the development of H. pylori-induced chron...

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Veröffentlicht in:Biochemical and biophysical research communications 2011-08, Vol.412 (2), p.266-272
Hauptverfasser: Kido, Masahiro, Watanabe, Norihiko, Aoki, Nobuhiro, Iwamoto, Satoru, Nishiura, Hisayo, Maruoka, Ryutaro, Ikeda, Aki, Azuma, Takeshi, Chiba, Tsutomu
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Sprache:eng
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Helicobacter pylori
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Zusammenfassung:Cytotoxin-associated gene A (CagA) acts directly on gastric epithelial cells. However, the roles of CagA in host adaptive immunity against Helicobacter pylori (H. pylori) infection are not fully understood. In this study, to investigate the roles of CagA in the development of H. pylori-induced chronic gastritis, we used an adoptive-transfer model in which spleen cells from C57BL/6 mice with or without H. pylori infection were transferred into RAG2-/-mice, with gastric colonization of either CagA+
ISSN:0006-291X
DOI:10.1016/j.bbrc.2011.07.081