Upregulation of heme oxygenase-1 via PI3K/Akt and Nrf-2 signaling pathways mediates the anti-inflammatory activity of Schisandrin in Porphyromonas gingivalis LPS-stimulated macrophages

Highlights ► In this study, we showed the anti-inflammatory potential of Schisandrin by using P. gingivalis LPS-stimulated RAW 26.7 cells. ► Our results also show that Schisandrin effectively inhibited the P. gingivalis LPS-induced proinflammatory response by upregulating HO-1 expression mediated by...

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Veröffentlicht in:	Immunology letters 2011-09, Vol.139 (1), p.93-101
Hauptverfasser:	Park, Sun Young, Park, Da Jung, Kim, Young Hun, Kim, YoungHee, Kim, Sun Gun, Shon, Kwang Jae, Choi, Young-Whan, Lee, Sang-Joon
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Allergy and Immunology Animals Anti-Inflammatory Agents - chemistry Anti-Inflammatory Agents - isolation & purification Anti-Inflammatory Agents - pharmacology Antiinflammatory agents Cell Line Cell Nucleus - metabolism Cyclooctanes - chemistry Cyclooctanes - isolation & purification Cyclooctanes - pharmacology Enzyme Activation - drug effects Extracellular signal-regulated kinase Fruits GA-binding protein Gene Expression Regulation - drug effects Heme oxygenase (decyclizing) Heme oxygenase-1 Heme Oxygenase-1 - genetics Heme Oxygenase-1 - metabolism Inflammation Inflammation - immunology Inflammation - metabolism Inflammation Mediators - metabolism Interleukin 1 Interleukin 6 Lignans - chemistry Lignans - isolation & purification Lignans - pharmacology Lipopolysaccharides Lipopolysaccharides - immunology Macrophages Macrophages - drug effects Macrophages - immunology Macrophages - metabolism Mice NF- Kappa B protein NF-E2-Related Factor 2 - metabolism NF-kappa B - metabolism NF-κB Nrf-2 Nuclear transport Periodontitis Phosphatidylinositol 3-Kinases - metabolism Phosphorylation Polycyclic Compounds - chemistry Polycyclic Compounds - isolation & purification Polycyclic Compounds - pharmacology Porphyromonas gingivalis Porphyromonas gingivalis - immunology Porphyromonas gingivalis LPS Pro-inflammatory cytokine Protein Transport - drug effects Proto-Oncogene Proteins c-akt - metabolism Schisandra Schisandrin Signal transduction Signal Transduction - immunology siRNA Tumor necrosis factor- alpha Up-Regulation - genetics
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Zusammenfassung:	Highlights ► In this study, we showed the anti-inflammatory potential of Schisandrin by using P. gingivalis LPS-stimulated RAW 26.7 cells. ► Our results also show that Schisandrin effectively inhibited the P. gingivalis LPS-induced proinflammatory response by upregulating HO-1 expression mediated by PI3K/Akt, ERK, and Nrf-2 signals. ► Schisandrin might be considered as a candidate for further development in the treatment of periodontitis and chronic inflammatory diseases.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2011.05.007