Let-7 family miRNAs regulate estrogen receptor alpha signaling in estrogen receptor positive breast cancer

In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA from formalin-fixed paraffin-embedded (FFPE) breast tissues, which included benign ( n = 13), ductal carcinoma in situ (DCIS) ( n = 16), and invasive...

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Veröffentlicht in:	Breast cancer research and treatment 2011-05, Vol.127 (1), p.69-80
Hauptverfasser:	Zhao, Yingchun, Deng, Caishu, Wang, Jiarui, Xiao, Jing, Gatalica, Zoran, Recker, Robert R., Xiao, Gary Guishan
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Base Sequence Biological and medical sciences Breast cancer Breast Neoplasms - genetics Breast Neoplasms - metabolism Cancer Cancer research Cancer therapies Care and treatment Cell Line, Tumor Cell Proliferation Comparative analysis Diagnosis Estrogen Estrogen Receptor alpha - metabolism Estrogens Female Formaldehyde Gene Expression Profiling Gene Expression Regulation, Neoplastic Gynecology. Andrology. Obstetrics Humans Luciferase Mammary gland diseases Medical sciences Medicine Medicine & Public Health MicroRNA MicroRNAs - genetics MicroRNAs - metabolism Oncology Phenols Preclinical Study Ribonucleic acid RNA Signal Transduction Tumors
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Zusammenfassung:	In order to understand how microRNAs (miRNAs) regulate breast cancer tumorigenesis, a miRNA expression microarray screening was performed using RNA from formalin-fixed paraffin-embedded (FFPE) breast tissues, which included benign ( n = 13), ductal carcinoma in situ (DCIS) ( n = 16), and invasive ductal carcinoma (IDC) ( n = 15). Twenty-five differentially expressed miRNAs ( P
ISSN:	0167-6806 1573-7217
DOI:	10.1007/s10549-010-0972-2