Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives

Synthesis and antiviral evaluation of 1,3-dimethyl-6-(1H-1,2,3-triazol-1-YL)pyrimidine-2,4(1H,3H)-dione derivatives

Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strai...

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Veröffentlicht in:Chemistry of heterocyclic compounds (New York, N.Y. 1965) N.Y. 1965), 2010-12, Vol.46 (9), p.1105-1108
Hauptverfasser: El-Etrawy, A. Sh, Abdel-Rahman, A. A.-H
Format: Artikel
Sprache:eng
Schlagworte:
1,2,3-triazoles
anti hepatitis A virus
Chemistry
Chemistry and Materials Science
cycloaddition
Hepatitis A virus
Organic Chemistry
Pharmacy
pyrimidine derivatives
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Zusammenfassung:Some 6-(1H-1,2,3-triazol-1-yl)pyrimidine-2,4(1H,3H)-dione derivatives were synthesized via the reaction of 6-azido-1,3-dimethyluracil with ethyl acetoacetate in the presence of sodium ethoxide. The antiviral activities of these compounds against Hepatitis A virus (HAV, MBB-cell culture adapted strain) and Herpes simples virus type-1 (HSV-1) were tested.
ISSN:0009-3122
1573-8353
DOI:10.1007/s10593-010-0633-8