An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells
Highlights ► APG, an acidic polysaccharide of Panax ginseng . ► APG regulates inflammatory and encephalitogenic response in experimental autoimmune encephalomyelitis (EAE). ► APG induces clinically beneficial effects for its therapeutic immunosuppression of EAE.
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| Veröffentlicht in: | Immunology letters 2011-08, Vol.138 (2), p.169-178 |
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| container_title | Immunology letters |
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| creator | Hwang, Insun Ahn, Ginnae Park, Eunjin Ha, Danbee Song, Jie-Young Jee, Youngheun |
| description | Highlights ► APG, an acidic polysaccharide of Panax ginseng . ► APG regulates inflammatory and encephalitogenic response in experimental autoimmune encephalomyelitis (EAE). ► APG induces clinically beneficial effects for its therapeutic immunosuppression of EAE. |
| doi_str_mv | 10.1016/j.imlet.2011.04.005 |
| format | Article |
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drug effects</subject><subject>CD25 antigen</subject><subject>Cell activation</subject><subject>Cell proliferation</subject><subject>Cell Proliferation - drug effects</subject><subject>Central nervous system (CNS)</subject><subject>Cytokines</subject><subject>Demyelinating diseases</subject><subject>Encephalomyelitis, Autoimmune, Experimental - drug therapy</subject><subject>Encephalomyelitis, Autoimmune, Experimental - genetics</subject><subject>Encephalomyelitis, Autoimmune, Experimental - immunology</subject><subject>Encephalomyelitis, Autoimmune, Experimental - pathology</subject><subject>Experimental allergic encephalomyelitis</subject><subject>Experimental autoimmune encephalomyelitis (EAE)</subject><subject>Female</subject><subject>Forkhead Transcription Factors - genetics</subject><subject>Forkhead Transcription Factors - metabolism</subject><subject>Foxp3 protein</subject><subject>gamma -Interferon</subject><subject>Ginseng</subject><subject>Humans</subject><subject>Immunomodulation</subject><subject>Immunoregulation</subject><subject>Immunosuppression</subject><subject>Immunosuppressive Agents - pharmacology</subject><subject>Immunosuppressive Agents - therapeutic use</subject><subject>Inflammation</subject><subject>Interferon-gamma - biosynthesis</subject><subject>Interleukin 1</subject><subject>Interleukin 17</subject><subject>Interleukin-10 - biosynthesis</subject><subject>Interleukin-17 - biosynthesis</subject><subject>Lethality</subject><subject>Lymphocyte Activation - drug effects</subject><subject>Lymphocyte Depletion</subject><subject>Lymphocytes T</subject><subject>Mice</subject><subject>Mice, Inbred C57BL</subject><subject>Multiple sclerosis</subject><subject>Multiple Sclerosis - drug therapy</subject><subject>Multiple Sclerosis - genetics</subject><subject>Multiple Sclerosis - immunology</subject><subject>Multiple Sclerosis - pathology</subject><subject>Natural killer cells</subject><subject>Panax - chemistry</subject><subject>Panax ginseng</subject><subject>Plant Extracts - chemistry</subject><subject>Polysaccharides</subject><subject>Polysaccharides - pharmacology</subject><subject>Polysaccharides - therapeutic use</subject><subject>T-Lymphocytes, Regulatory - drug effects</subject><subject>T-Lymphocytes, Regulatory - immunology</subject><subject>Th1 Cells - drug effects</subject><subject>Th1 Cells - immunology</subject><subject>Transcription factors</subject><subject>Transcription, Genetic - drug effects</subject><subject>Transcription, Genetic - immunology</subject><subject>Transcriptional Activation - drug effects</subject><subject>Transcriptional Activation - immunology</subject><issn>0165-2478</issn><issn>1879-0542</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkk9v1DAQxS0EokvhEyAh3zgl2I7jeA8gVRX_pEogUc6WY0-2Xhw72EnVXPjsOGzhwKWnufzezOi9h9BLSmpKqHhzrN3oYa4ZobQmvCakfYR2VHb7irScPUa7QrUV4508Q89yPhJC24Y3T9EZoy3jQogd-nURsDbOOoOn6NesjbnRyVnAccBfddB3-OBChnDAegTvYtIzZAx3EyQ3Qpi1x3qZoxvHJQCGYGC60T6Oa4Fnl7EOFrtgF1NUCQ6L13NMK77GBrzPz9GTQfsML-7nOfr-4f315afq6svHz5cXV5XhvJ0rJqwWXHe9tJIMkvGe6M70vRXC7o1oQPe2510ju4EN1khmZE_BdJLa3hBJm3P0-rR3SvHnAnlWo8vbBzpAXLLaE84lEaJ7kJQdJ7RjpClkcyJNijknGNRULNFpVZSoLSF1VH8SUltCinBVEiqqV_f7l34E-0_zN5ICvD0BUPy4dZBUNm7z1boEZlY2ugcOvPtPb7wLzmj_A1bIx7ikUKxWVGWmiPq2lWTrCKWlH4yS5jfMn7ta</recordid><startdate>20110830</startdate><enddate>20110830</enddate><creator>Hwang, Insun</creator><creator>Ahn, Ginnae</creator><creator>Park, Eunjin</creator><creator>Ha, Danbee</creator><creator>Song, Jie-Young</creator><creator>Jee, Youngheun</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20110830</creationdate><title>An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells</title><author>Hwang, Insun ; Ahn, Ginnae ; Park, Eunjin ; Ha, Danbee ; Song, Jie-Young ; Jee, Youngheun</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c445t-26da64a7b8d80f824b0a7cbbd66d9c63eabdb47387f2fdc82c8b1ec781dbc0813</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Acidic polysaccharide</topic><topic>Allergy and Immunology</topic><topic>Animal models</topic><topic>Animals</topic><topic>Autoimmune diseases</topic><topic>Autoimmunity - drug effects</topic><topic>CD25 antigen</topic><topic>Cell activation</topic><topic>Cell proliferation</topic><topic>Cell Proliferation - drug effects</topic><topic>Central nervous system (CNS)</topic><topic>Cytokines</topic><topic>Demyelinating diseases</topic><topic>Encephalomyelitis, Autoimmune, Experimental - drug therapy</topic><topic>Encephalomyelitis, Autoimmune, Experimental - genetics</topic><topic>Encephalomyelitis, Autoimmune, Experimental - immunology</topic><topic>Encephalomyelitis, Autoimmune, Experimental - pathology</topic><topic>Experimental allergic encephalomyelitis</topic><topic>Experimental autoimmune encephalomyelitis (EAE)</topic><topic>Female</topic><topic>Forkhead Transcription Factors - genetics</topic><topic>Forkhead Transcription Factors - metabolism</topic><topic>Foxp3 protein</topic><topic>gamma -Interferon</topic><topic>Ginseng</topic><topic>Humans</topic><topic>Immunomodulation</topic><topic>Immunoregulation</topic><topic>Immunosuppression</topic><topic>Immunosuppressive Agents - pharmacology</topic><topic>Immunosuppressive Agents - therapeutic use</topic><topic>Inflammation</topic><topic>Interferon-gamma - biosynthesis</topic><topic>Interleukin 1</topic><topic>Interleukin 17</topic><topic>Interleukin-10 - biosynthesis</topic><topic>Interleukin-17 - biosynthesis</topic><topic>Lethality</topic><topic>Lymphocyte Activation - drug effects</topic><topic>Lymphocyte Depletion</topic><topic>Lymphocytes T</topic><topic>Mice</topic><topic>Mice, Inbred C57BL</topic><topic>Multiple sclerosis</topic><topic>Multiple Sclerosis - drug therapy</topic><topic>Multiple Sclerosis - genetics</topic><topic>Multiple Sclerosis - immunology</topic><topic>Multiple Sclerosis - pathology</topic><topic>Natural killer cells</topic><topic>Panax - chemistry</topic><topic>Panax ginseng</topic><topic>Plant Extracts - chemistry</topic><topic>Polysaccharides</topic><topic>Polysaccharides - pharmacology</topic><topic>Polysaccharides - therapeutic use</topic><topic>T-Lymphocytes, Regulatory - drug effects</topic><topic>T-Lymphocytes, Regulatory - 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| identifier | ISSN: 0165-2478 |
| ispartof | Immunology letters, 2011-08, Vol.138 (2), p.169-178 |
| issn | 0165-2478 1879-0542 |
| language | eng |
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| source | MEDLINE; ScienceDirect Journals (5 years ago - present) |
| subjects | Acidic polysaccharide Allergy and Immunology Animal models Animals Autoimmune diseases Autoimmunity - drug effects CD25 antigen Cell activation Cell proliferation Cell Proliferation - drug effects Central nervous system (CNS) Cytokines Demyelinating diseases Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Experimental autoimmune encephalomyelitis (EAE) Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 protein gamma -Interferon Ginseng Humans Immunomodulation Immunoregulation Immunosuppression Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Inflammation Interferon-gamma - biosynthesis Interleukin 1 Interleukin 17 Interleukin-10 - biosynthesis Interleukin-17 - biosynthesis Lethality Lymphocyte Activation - drug effects Lymphocyte Depletion Lymphocytes T Mice Mice, Inbred C57BL Multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - pathology Natural killer cells Panax - chemistry Panax ginseng Plant Extracts - chemistry Polysaccharides Polysaccharides - pharmacology Polysaccharides - therapeutic use T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - drug effects Th1 Cells - immunology Transcription factors Transcription, Genetic - drug effects Transcription, Genetic - immunology Transcriptional Activation - drug effects Transcriptional Activation - immunology |
| title | An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells |
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