An acidic polysaccharide of Panax ginseng ameliorates experimental autoimmune encephalomyelitis and induces regulatory T cells

Highlights ► APG, an acidic polysaccharide of Panax ginseng . ► APG regulates inflammatory and encephalitogenic response in experimental autoimmune encephalomyelitis (EAE). ► APG induces clinically beneficial effects for its therapeutic immunosuppression of EAE.

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Bibliographische Detailangaben
Veröffentlicht in:	Immunology letters 2011-08, Vol.138 (2), p.169-178
Hauptverfasser:	Hwang, Insun, Ahn, Ginnae, Park, Eunjin, Ha, Danbee, Song, Jie-Young, Jee, Youngheun
Format:	Artikel
Sprache:	eng
Schlagworte:	Acidic polysaccharide Allergy and Immunology Animal models Animals Autoimmune diseases Autoimmunity - drug effects CD25 antigen Cell activation Cell proliferation Cell Proliferation - drug effects Central nervous system (CNS) Cytokines Demyelinating diseases Encephalomyelitis, Autoimmune, Experimental - drug therapy Encephalomyelitis, Autoimmune, Experimental - genetics Encephalomyelitis, Autoimmune, Experimental - immunology Encephalomyelitis, Autoimmune, Experimental - pathology Experimental allergic encephalomyelitis Experimental autoimmune encephalomyelitis (EAE) Female Forkhead Transcription Factors - genetics Forkhead Transcription Factors - metabolism Foxp3 protein gamma -Interferon Ginseng Humans Immunomodulation Immunoregulation Immunosuppression Immunosuppressive Agents - pharmacology Immunosuppressive Agents - therapeutic use Inflammation Interferon-gamma - biosynthesis Interleukin 1 Interleukin 17 Interleukin-10 - biosynthesis Interleukin-17 - biosynthesis Lethality Lymphocyte Activation - drug effects Lymphocyte Depletion Lymphocytes T Mice Mice, Inbred C57BL Multiple sclerosis Multiple Sclerosis - drug therapy Multiple Sclerosis - genetics Multiple Sclerosis - immunology Multiple Sclerosis - pathology Natural killer cells Panax - chemistry Panax ginseng Plant Extracts - chemistry Polysaccharides Polysaccharides - pharmacology Polysaccharides - therapeutic use T-Lymphocytes, Regulatory - drug effects T-Lymphocytes, Regulatory - immunology Th1 Cells - drug effects Th1 Cells - immunology Transcription factors Transcription, Genetic - drug effects Transcription, Genetic - immunology Transcriptional Activation - drug effects Transcriptional Activation - immunology
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Beschreibung
Zusammenfassung:	Highlights ► APG, an acidic polysaccharide of Panax ginseng . ► APG regulates inflammatory and encephalitogenic response in experimental autoimmune encephalomyelitis (EAE). ► APG induces clinically beneficial effects for its therapeutic immunosuppression of EAE.
ISSN:	0165-2478 1879-0542
DOI:	10.1016/j.imlet.2011.04.005