Cracking the Code: Dopamine Signaling in Cocaine Dependence

[...] questions about the interpretation of the findings of impaired (reduced) dopamine signaling in cocaine dependence remain. [...] multiple brain systems (e.g., cognition, motivation, reward), neurotransmitters (e.g., glutamate, [gamma]-aminobutyric acid), and associated regions (e.g., orbitofron...

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Veröffentlicht in:	The American journal of psychiatry 2011-06, Vol.168 (6), p.572-575
1. Verfasser:	Martis, Brian
Format:	Artikel
Sprache:	eng
Schlagworte:	Biomarkers - metabolism Brain - metabolism Cocaine Cocaine-Related Disorders - metabolism Dopamine Dopamine - metabolism Drug addiction Humans Positron-Emission Tomography Psychopharmacology Signal Transduction Substance abuse treatment
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Beschreibung
Zusammenfassung:	[...] questions about the interpretation of the findings of impaired (reduced) dopamine signaling in cocaine dependence remain. [...] multiple brain systems (e.g., cognition, motivation, reward), neurotransmitters (e.g., glutamate, [gamma]-aminobutyric acid), and associated regions (e.g., orbitofrontal, cingulate) are likely to be involved in cocaine dependence.
ISSN:	0002-953X 1535-7228
DOI:	10.1176/appi.ajp.2011.11030470