IgGs containing light chains of the λ and κ type and of all subclasses (IgG1-IgG4) from sera of patients with multiple sclerosis hydrolyze DNA

We present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1–IgG4) are catalytically active in the hydrolysis of DNA and on average their relative activity (nM supercoiled DNA/1mg IgG/1 h) increases in the order: IgG1 (0.58)

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Bibliographische Detailangaben
Veröffentlicht in:	Journal of molecular recognition 2010-09, Vol.23 (5), p.486-494
Hauptverfasser:	Parkhomenko, Taisiya A., Legostaeva, Galina A., Doronin, Boris M., Buneva, Valentina N., Nevinsky, Georgy A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult catalytic IgG DNA - metabolism Female human blood antibodies Humans Hydrolysis hydrolysis of DNA Immunoglobulin G - chemistry Immunoglobulin G - metabolism Immunoglobulin kappa-Chains - chemistry Immunoglobulin lambda-Chains - chemistry Male Middle Aged multiple sclerosis Multiple Sclerosis - blood Multiple Sclerosis - genetics Multiple Sclerosis - immunology Young Adult
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Beschreibung
Zusammenfassung:	We present the first evidence demonstrating that small fractions of IgGs of all four subclasses (IgG1–IgG4) are catalytically active in the hydrolysis of DNA and on average their relative activity (nM supercoiled DNA/1mg IgG/1 h) increases in the order: IgG1 (0.58)
ISSN:	0952-3499 1099-1352 1099-1352
DOI:	10.1002/jmr.1016