Radiopharmaceutical management of super(90)Y/ super(111)In labeled antibodies: shielding and quantification during preparation and administration

Background: The combined application of potent b-emitting isotopes for therapy with g-emitting isotopes for scintigraphy requires a profound regimen concerning team member safety and radionuclide quantification. Methods: We have developed materials and methods for a proper and easy manipulation of super(90)Y during preparation and administration of super(90)Y/ super(111)In pharmaceuticals used for radioimmunotherapy. Results: The efficacy of the shielding measures is documented. Protocols for the calibration of b-dose calibrators with respect to super(90)Y are extended to the assessment of quench-corrected liquid scintillation counting of super(90)Y. The contribution of super(90)Y backscatter to super(111)In counting is quantified. Newly developed shielding equipment allows an adequate administration of relatively large volumes (100ml) of super(90)Y/ super(111)In labeled pharmaceuticals to patients. Conclusions: The procedures described combine pharmaceutical (Good Manufacturing Practice) and radiation safety requirements with an accurate logging of relevant data.