Synthesis and antibacterial activity of chalcones bearing prenyl or geranyl groups from Angelica keiskei

Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin ( 1a), xanthoangelol ( 1e), xanthoangelol F ( 1f), xanthoangelol H ( 2), deoxyxanthoangelol H ( 3), and deoxydihydroxanthoangelol H ( 4) and their derivatives were synthesized. From the evaluation of antibact...

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Veröffentlicht in:	Tetrahedron 2011-07, Vol.67 (29), p.5346-5359
Hauptverfasser:	Sugamoto, Kazuhiro, Matsusita, Yoh-ichi, Matsui, Kana, Kurogi, Chiaki, Matsui, Takanao
Format:	Artikel
Sprache:	eng
Schlagworte:	[1,3]-Sigmatropic rearrangement Angelica Angelica keiskei Antibacterial activity Antibacterial agents Antibiotics. Antiinfectious agents. Antiparasitic agents Antiinfectives and antibacterials Bacteria Bearing Biological and medical sciences Chemistry Derivatives Exact sciences and technology General pharmacology Geranylated chalcone Heterocyclic compounds Heterocyclic compounds with o, s, se, te hetero atom and condensed derivatives Medical sciences Organic chemistry Pharmacognosy. Homeopathy. Health food Pharmacology. Drug treatments Prenylated chalcone Preparations and properties Synthesis (chemistry) Tetrahedrons
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Zusammenfassung:	Chalcones bearing prenyl or geranyl groups from Angelica keiskei, such as 4-hydroxyderricin ( 1a), xanthoangelol ( 1e), xanthoangelol F ( 1f), xanthoangelol H ( 2), deoxyxanthoangelol H ( 3), and deoxydihydroxanthoangelol H ( 4) and their derivatives were synthesized. From the evaluation of antibacterial activity of the synthesized chalcones, 1a, isobavachalcone ( 1b), 1e, 1f, bavachalcone ( 5a), and broussochalcone B ( 5b) were found to inhibit Gram-positive bacteria. [Display omitted]
ISSN:	0040-4020 1464-5416
DOI:	10.1016/j.tet.2011.04.104