Cerebrospinal fluid phospholipase C activity increases in migraine

Background: Adrenaline, serotonin, cannabinoid and estrogen receptors are involved in migraine pathophysiology. The signaling of these receptors change phosphatidylcholine-specific phospholipase C (PC-PLC) activity, but there have been no reported PC-PLC studies in migraine. Methods: We identified P...

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Veröffentlicht in:	Cephalalgia 2011-03, Vol.31 (4), p.456-462
Hauptverfasser:	Fonteh, Alfred N, Chung, Rainbow, Sharma, Tara L, Fisher, R Danielle, Pogoda, Janice M, Cowan, Robert, Harrington, Michael G
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Biomarkers - blood Biomarkers - cerebrospinal fluid Bridged-Ring Compounds - pharmacology Enzyme Activation - drug effects Female Humans Male Middle Aged Migraine Disorders - blood Migraine Disorders - cerebrospinal fluid Migraine Disorders - enzymology Phosphatidylcholines - cerebrospinal fluid Thiones - pharmacology Type C Phospholipases - blood Type C Phospholipases - cerebrospinal fluid
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Zusammenfassung:	Background: Adrenaline, serotonin, cannabinoid and estrogen receptors are involved in migraine pathophysiology. The signaling of these receptors change phosphatidylcholine-specific phospholipase C (PC-PLC) activity, but there have been no reported PC-PLC studies in migraine. Methods: We identified PC-PLC activity in blood and cerebrospinal fluid (CSF), and quantified it in samples from ictal and interictal migraineurs without aura and healthy controls. Results: Pre-incubation with a specific PC-PLC inhibitor, D609, inhibited enzyme activity (p
ISSN:	0333-1024 1468-2982
DOI:	10.1177/0333102410383589