BJSM reviews: A to Z of nutritional supplements: dietary supplements, sports nutrition foods and ergogenic aids for health and performance—Part 18

Disulphide formation and gluathionylation are reversible forms of protein covalent modification dependent on glutathione and can provide mechanisms for regulation of metabolic, signalling and transcriptional processes, 3 including skeletal muscle adaptation to exercise and training. 4 The cellular redox state is crucial for molecular signalling, and glutathione is a key regulator/sensor for redox status; thus strategies aiming at increasing GSH synthesis should be beneficial to exercise performance. Because of the importance of glutathione as a key regulator or sensor for redox status, increasing GSH synthesis may be beneficial to exercise performance. [...]amino acid supplementation that increases intracellular glutamate and cysteine might improve muscle GSH synthesis.