Effects of intense exercise in chronic spinal cord injury

Background: Exercise has beneficial effects on muscle and motor function after spinal cord injury (SCI). Little is known regarding effects of prolonged intense exercise (IE) in humans with chronic SCI. Design: Prospective, non-randomized, controlled observational study. The intervention was either a...

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Veröffentlicht in:Spinal cord 2008-11, Vol.46 (11), p.733-737
Hauptverfasser: Harness, E T, Yozbatiran, N, Cramer, S C
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Sprache:eng
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Zusammenfassung:Background: Exercise has beneficial effects on muscle and motor function after spinal cord injury (SCI). Little is known regarding effects of prolonged intense exercise (IE) in humans with chronic SCI. Design: Prospective, non-randomized, controlled observational study. The intervention was either a multimodal IE program ( n =21) or a control (CTL) intervention consisting of self-regulated exercise ( n =8). Objective: Measure sensorimotor function over 6 months in relation to an IE program. Setting: Single outpatient center. Subjects: Subjects with chronic SCI ( n =29 total), mainly ASIA Impairment Scale A and B, injury levels C4-T11. Results: Baseline neurological assessments (for example, ASIA motor score, 39±3 vs 42±5, IE vs CTL, P >0.5, mean±s.e.m.) did not differ between the two groups. During the 6 months, IE subjects averaged 7.3±0.7 h per week exercise, not significantly different from CTL subjects (5.2±1.3 h per week, P >0.1). However, after 6 months, IE subjects showed significantly greater motor gains than CTL subjects in the main outcome measure, ASIA motor score (change of 4.8±1.0 vs −0.1±0.5 points, P =0.0001). The main outcome measure was calculated by ASIA motor score. These IE subject ASIA motor gains correlated with number of exercise hours per week ( r =0.53, P
ISSN:1362-4393
1476-5624
DOI:10.1038/sc.2008.56