Halichonines A, B, and C, novel sesquiterpene alkaloids from the marine sponge Halichondria okadai Kadota

Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 indu...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-12, Vol.47 (46), p.12453-12455
Hauptverfasser:	Ohno, Osamu, Chiba, Tatsuhiko, Todoroki, Seiji, Yoshimura, Hideaki, Maru, Norihito, Maekawa, Ken, Imagawa, Hiroshi, Yamada, Kaoru, Wakamiya, Atsushi, Suenaga, Kiyotake, Uemura, Daisuke
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids Alkaloids - chemistry Alkaloids - isolation & purification Alkaloids - pharmacology Amines Animals Antineoplastic Agents - chemistry Antineoplastic Agents - isolation & purification Antineoplastic Agents - pharmacology HL-60 Cells Human Humans Inhibitory Concentration 50 Leukemias Marine Models, Molecular Molecular Conformation Porifera - chemistry Sesquiterpenes - chemistry Sesquiterpenes - isolation & purification Sesquiterpenes - pharmacology Spectroscopic analysis Sponges Synthesis
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Zusammenfassung:	Novel sesquiterpene alkaloids, halichonines A (1), B (2), and C (3), were identified from the marine sponge Halichondria okadai Kadota. By spectroscopic analyses and synthesis, their structures were revealed to include a 6,6-bicyclic ring system and two prenylated amine moieties. In addition, 2 induced apoptosis in HL60 human leukemia cells.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc15557a