Simultaneous immunoassay for the detection of two lung cancer markers using functionalized SERS nanoprobes

A quick and reproducible SERS-based immunoassay, using functionalized hollow gold nanospheres and magnetic beads, has been developed. Here, a simultaneous detection of dual cancer markers in blood serum has been achieved under a single excitation wavelength. The accuracy and sensitivity for clinical...

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Veröffentlicht in:	Chemical communications (Cambridge, England) England), 2011-12, Vol.47 (46), p.12515-12517
Hauptverfasser:	Chon, Hyangah, Lee, Sangyeop, Yoon, Soo-Young, Chang, Soo-Ik, Lim, Dong Woo, Choo, Jaebum
Format:	Artikel
Sprache:	eng
Schlagworte:	alpha-Fetoproteins - analysis Biomarkers, Tumor - blood Carcinoembryonic Antigen - blood Gold - chemistry Humans Immunoassay - methods Lung Neoplasms - blood Metal Nanoparticles - chemistry Spectrum Analysis, Raman - methods Time Factors
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Beschreibung
Zusammenfassung:	A quick and reproducible SERS-based immunoassay, using functionalized hollow gold nanospheres and magnetic beads, has been developed. Here, a simultaneous detection of dual cancer markers in blood serum has been achieved under a single excitation wavelength. The accuracy and sensitivity for clinical sera from five patients confirms their diagnostic feasibility.
ISSN:	1359-7345 1364-548X
DOI:	10.1039/c1cc15707h