Goiter, cardiovascular and metabolic disorders in patients with acromegaly

This study evaluated the relationship between selected acromegaly complications such as IGF-1 serum concentrations at diagnosis as well as of controlled and uncontrolled disease. A total of 113 acromegaly patients were enrolled to the study and the duration of active and uncontrolled disease was eva...

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Veröffentlicht in:	Endocrine regulations (Bratislava) 2011-10, Vol.45 (4), p.191-197
Hauptverfasser:	Golkowski, F, Krzentowska-Korek, A, Baldys-Waligorska, A, Hubalewska-Dydejczyk, A
Format:	Artikel
Sprache:	eng
Schlagworte:	Acromegaly - epidemiology Adult Diabetes Mellitus - epidemiology Female Glucose Intolerance - epidemiology Goiter - epidemiology Human Growth Hormone - blood Humans Hypercholesterolemia - epidemiology Hypertension - epidemiology Hypertriglyceridemia - epidemiology Insulin-Like Growth Factor I - metabolism Male Metabolic Diseases - epidemiology Middle Aged Myocardial Ischemia - epidemiology Prevalence Risk Factors
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Beschreibung
Zusammenfassung:	This study evaluated the relationship between selected acromegaly complications such as IGF-1 serum concentrations at diagnosis as well as of controlled and uncontrolled disease. A total of 113 acromegaly patients were enrolled to the study and the duration of active and uncontrolled disease was evaluated as a crucial cause of selected complications. Goiter, diabetes, hypercholesterolemia, hypertriglycerydemia, hypertension and ischemic heart disease were diagnosed in 85(75.2 %), 23(20.3 %), 48(51.0 %), 15(13.3 %), 65(57.5 %) and 18(15.9%) patients, respectively. Prevalence of goiter and diabetes was significantly related to the duration of uncontrolled acromegaly (p
ISSN:	1210-0668 1336-0329 1336-0329
DOI:	10.4149/endo_2011_04_191