The kinetics of cohesive powder de-agglomeration from three inhaler devices

The kinetics of cohesive powder de-agglomeration from three inhaler devices

The purpose of the current investigation is to understand the kinetics of de-agglomeration (kd) of micronised salbutamol sulphate (SS) and lactohale 300 (LH300) under varying air flow rates (30–180lmin−1) from three dry powder inhaler devices (DPIs), Rotahaler® (RH), Monodose Inhaler® (MI) and Handi...

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Veröffentlicht in:International journal of pharmaceutics 2011-12, Vol.421 (1), p.72-81
Hauptverfasser: Behara, Srinivas Ravindra Babu, Larson, Ian, Kippax, Paul, Morton, David A.V., Stewart, Peter
Format: Artikel
Sprache:eng
Schlagworte:
Aerosols
air flow
Air Movements
Albuterol - chemistry
Biological and medical sciences
De-agglomeration
Dry powder inhaler
General pharmacology
Kinetics
Laser diffraction
least squares
Medical sciences
Nebulizers and Vaporizers
Non-linear regression modelling
Particle Size
particle size distribution
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Powders - chemistry
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Zusammenfassung:The purpose of the current investigation is to understand the kinetics of de-agglomeration (kd) of micronised salbutamol sulphate (SS) and lactohale 300 (LH300) under varying air flow rates (30–180lmin−1) from three dry powder inhaler devices (DPIs), Rotahaler® (RH), Monodose Inhaler® (MI) and Handihaler® (HH). Cumulative fine particle mass vs. time profiles were obtained from the powder concentration, emitted mass and volume percent
ISSN:0378-5173
1873-3476
DOI:10.1016/j.ijpharm.2011.09.024