Galectin-3 – A jack-of-all-trades in cancer

Galectin-3 – A jack-of-all-trades in cancer

Highlights ► Galectin-3 has multiple inter- and sub-cellular localizations. ► Alterations of galectin-3 expression and localization are common in cancer. ► Galectin-3 regulates cancer development, progression and metastasis. ► Galectin-3 interacts with different ligands at different localizations....

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Veröffentlicht in:Cancer letters 2011-12, Vol.313 (2), p.123-128
Hauptverfasser: Newlaczyl, Anna U, Yu, Lu-Gang
Format: Artikel
Sprache:eng
Schlagworte:
adhesion
angiogenesis
Apoptosis
Apoptosis - physiology
Breast cancer
Cancer adhesion
Carbohydrates
carcinogenesis
Cell adhesion & migration
Cell Adhesion - physiology
Cell growth
Cytoplasm
Endothelium
Galectin 3 - chemistry
Galectin 3 - metabolism
Galectin-3
Gene expression
Hematology, Oncology and Palliative Medicine
Humans
Ligands
Medical prognosis
Medical research
Metastasis
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms - metabolism
Neoplasms - pathology
Neovascularization, Pathologic - metabolism
Progression
Proteins
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Beschreibung
Zusammenfassung:Highlights ► Galectin-3 has multiple inter- and sub-cellular localizations. ► Alterations of galectin-3 expression and localization are common in cancer. ► Galectin-3 regulates cancer development, progression and metastasis. ► Galectin-3 interacts with different ligands at different localizations.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2011.09.003