Alginate films containing Lactobacillus plantarum as wound dressing for prevention of burn infection

Summary The topical application of lactobacilli is receiving attention for the prevention of superficial skin and burn wound infections. We studied the properties of Lactobacillus plantarum immobilized in calcium alginate films and investigated the antibacterial activity of these films in a model bu...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The Journal of hospital infection 2011-12, Vol.79 (4), p.375-377
Hauptverfasser:	Brachkova, M.I, Marques, P, Rocha, J, Sepodes, B, Duarte, M.A, Pinto, J.F
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Alginate films Alginates - administration & dosage Alginic acid Animals Antibacterial activity Antibiosis Bacterial Load Bandages Biological and medical sciences Burn infection Burn wounds Burns Burns - therapy calcium alginate Cells, Immobilized - physiology Clinical isolates Colony-forming cells Disease Models, Animal Diseases of the digestive system Dressings Drug Stability Freeze Drying Glucuronic Acid - administration & dosage Hexuronic Acids - administration & dosage Hospitals Infectious Disease Infectious diseases Lactobacillus Lactobacillus plantarum Lactobacillus plantarum - physiology Male Medical sciences Microbial Viability Pathogenic bacteria Probiotic Pseudomonas aeruginosa Pseudomonas aeruginosa - pathogenicity Pseudomonas Infections - prevention & control Radiotherapy. Instrumental treatment. Physiotherapy. Reeducation. Rehabilitation, orthophony, crenotherapy. Diet therapy and various other treatments (general aspects) Rats Rats, Wistar Skin Topical application Traumas. Diseases due to physical agents Wound infection Wounds Wounds and Injuries - therapy
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Summary The topical application of lactobacilli is receiving attention for the prevention of superficial skin and burn wound infections. We studied the properties of Lactobacillus plantarum immobilized in calcium alginate films and investigated the antibacterial activity of these films in a model burn wound in rats. A multiresistant clinical isolate, VIM-2-metallo-β-lactamase-producing Pseudomonas aeruginosa , was used as the indicator strain. Films incorporating L. plantarum at cell concentrations of 108 cfu/mL caused a reduction of 5–6 log10 in P. aeruginosa in the model burn wounds. L. plantarum immobilized in freeze-dried calcium alginate films remained viable during six months of storage at 4 °C.
ISSN:	0195-6701 1532-2939
DOI:	10.1016/j.jhin.2011.09.003