Selective N-Acylation and N-Alkylation of Biotin

Selective N-Acylation and N-Alkylation of Biotin

Simple and efficient methodology is presented for the selective acylation and alkylation of biotin at its 3′-nitrogen.

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Bibliographische Detailangaben
Veröffentlicht in:Journal of organic chemistry 2011-11, Vol.76 (22), p.9514-9518
Hauptverfasser: Pehere, Ashok D, Abell, Andrew D
Format: Artikel
Sprache:eng
Schlagworte:
Acylation
Alkylation
Biotin - chemistry
Chemistry
Exact sciences and technology
Heterocyclic compounds
Heterocyclic compounds with n hetero atom and also o and/or s, se, te hetero atoms
Molecular Structure
Organic chemistry
Preparations and properties
Stereoisomerism
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Beschreibung
Zusammenfassung:Simple and efficient methodology is presented for the selective acylation and alkylation of biotin at its 3′-nitrogen.
ISSN:0022-3263
1520-6904
DOI:10.1021/jo201615j