Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population
Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal. In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RD...
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| Veröffentlicht in: | Clinica chimica acta 2011-11, Vol.412 (23-24), p.2094-2099 |
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| container_title | Clinica chimica acta |
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| creator | Lappé, Jason M. Horne, Benjamin D. Shah, Svati H. May, Heidi T. Muhlestein, Joseph B. Lappé, Donald L. Kfoury, Abdallah G. Carlquist, John F. Budge, Deborah Alharethi, Rami Bair, Tami L. Kraus, William E. Anderson, Jeffrey L. |
| description | Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal.
In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RDW and its associations with inflammation, liver function, renal function, and body mass were assessed. A population of 449 normal (No-CAD) patients also was evaluated.
RDW predicted all-cause mortality in a step-wise manner (HR=1.37 per quintile; 95% CI=1.29, 1.46; p-trend |
| doi_str_mv | 10.1016/j.cca.2011.07.018 |
| format | Article |
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In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RDW and its associations with inflammation, liver function, renal function, and body mass were assessed. A population of 449 normal (No-CAD) patients also was evaluated.
RDW predicted all-cause mortality in a step-wise manner (HR=1.37 per quintile; 95% CI=1.29, 1.46; p-trend<0.001). A significant but meaningless correlation between RDW and high-sensitivity C-reactive protein (hsCRP) was identified (r=0.181; p<0.001). With full adjustment, RDW remained significant (p-trend<0.001) and the strongest predictor of mortality among all factors included in the model. RDW also strongly predicted all-cause mortality in the normal control population (HR=1.33 per quintile, CI=1.15, 1.55; p-trend<0.001), but hsCRP did not predict mortality among normal controls.
RDW was associated with mortality in patients with CAD and may provide clinically useful prognostication. Although RDW was correlated with hsCRP, they were independent predictors of mortality. RDW has been incorporated into risk prediction tool using data from basic chemistries available at: http://intermountainhealthcare.org/IMRS.
► Red cell distribution width (RDW) is associated with mortality in CAD patients. ► The etiology of RDW elevation is unknown. ► Elevation of RDW is not due to chronic inflammation as measured by hsCRP. ► RDW is also associated with mortality in controls and is not a coronary disease-specific or heart failure-specific marker. ► Despite an unknown pathophysiology, elevated RDW is a strong predictor of mortality.</description><identifier>ISSN: 0009-8981</identifier><identifier>EISSN: 1873-3492</identifier><identifier>DOI: 10.1016/j.cca.2011.07.018</identifier><identifier>PMID: 21821014</identifier><language>eng</language><publisher>Netherlands: Elsevier B.V</publisher><subject>Aged ; Blood Cell Count ; Blood cells ; C-Reactive Protein - metabolism ; Case-Control Studies ; CBC ; Coronary disease ; Coronary Disease - blood ; Coronary Disease - mortality ; Erythrocytes - metabolism ; Female ; Humans ; Male ; Middle Aged ; Mortality ; Proportional Hazards Models ; RDW</subject><ispartof>Clinica chimica acta, 2011-11, Vol.412 (23-24), p.2094-2099</ispartof><rights>2011 Elsevier B.V.</rights><rights>Copyright © 2011 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c352t-32861461df14bb1e5913723589fd0a27263a73506ce97d2e1881819f11053db43</citedby><cites>FETCH-LOGICAL-c352t-32861461df14bb1e5913723589fd0a27263a73506ce97d2e1881819f11053db43</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0009898111004165$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/21821014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lappé, Jason M.</creatorcontrib><creatorcontrib>Horne, Benjamin D.</creatorcontrib><creatorcontrib>Shah, Svati H.</creatorcontrib><creatorcontrib>May, Heidi T.</creatorcontrib><creatorcontrib>Muhlestein, Joseph B.</creatorcontrib><creatorcontrib>Lappé, Donald L.</creatorcontrib><creatorcontrib>Kfoury, Abdallah G.</creatorcontrib><creatorcontrib>Carlquist, John F.</creatorcontrib><creatorcontrib>Budge, Deborah</creatorcontrib><creatorcontrib>Alharethi, Rami</creatorcontrib><creatorcontrib>Bair, Tami L.</creatorcontrib><creatorcontrib>Kraus, William E.</creatorcontrib><creatorcontrib>Anderson, Jeffrey L.</creatorcontrib><title>Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population</title><title>Clinica chimica acta</title><addtitle>Clin Chim Acta</addtitle><description>Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal.
In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RDW and its associations with inflammation, liver function, renal function, and body mass were assessed. A population of 449 normal (No-CAD) patients also was evaluated.
RDW predicted all-cause mortality in a step-wise manner (HR=1.37 per quintile; 95% CI=1.29, 1.46; p-trend<0.001). A significant but meaningless correlation between RDW and high-sensitivity C-reactive protein (hsCRP) was identified (r=0.181; p<0.001). With full adjustment, RDW remained significant (p-trend<0.001) and the strongest predictor of mortality among all factors included in the model. RDW also strongly predicted all-cause mortality in the normal control population (HR=1.33 per quintile, CI=1.15, 1.55; p-trend<0.001), but hsCRP did not predict mortality among normal controls.
RDW was associated with mortality in patients with CAD and may provide clinically useful prognostication. Although RDW was correlated with hsCRP, they were independent predictors of mortality. RDW has been incorporated into risk prediction tool using data from basic chemistries available at: http://intermountainhealthcare.org/IMRS.
► Red cell distribution width (RDW) is associated with mortality in CAD patients. ► The etiology of RDW elevation is unknown. ► Elevation of RDW is not due to chronic inflammation as measured by hsCRP. ► RDW is also associated with mortality in controls and is not a coronary disease-specific or heart failure-specific marker. ► Despite an unknown pathophysiology, elevated RDW is a strong predictor of mortality.</description><subject>Aged</subject><subject>Blood Cell Count</subject><subject>Blood cells</subject><subject>C-Reactive Protein - metabolism</subject><subject>Case-Control Studies</subject><subject>CBC</subject><subject>Coronary disease</subject><subject>Coronary Disease - blood</subject><subject>Coronary Disease - mortality</subject><subject>Erythrocytes - metabolism</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Proportional Hazards Models</subject><subject>RDW</subject><issn>0009-8981</issn><issn>1873-3492</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2011</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc1q3DAUhUVpaKZpH6Cbol03Y0dX8o9MV2XoHwQCpV0LWbpmNNiWK8kJeZi8a-VM2mVX4sJ3ztW5h5B3wEpg0FyfSmN0yRlAydqSgXxBdiBbUYiq4y_JjjHWFbKTcElex3jKY8UaeEUuOUieHaodefyBlhocR2pdTMH1a3J-pvfOpuOeHoqA2iR3h3QJPqGb9zQdkRo_LSMmpP3ofdb7dU57qmdLJx-SHl16oG6mi04O5xSzXTpmKvhZh4dtE-qIT7ymsw-THp8sdXAxL1_8so56-8cbcjHoMeLb5_eK_Pry-efhW3Fz-_X74dNNYUTNUyG4bKBqwA5Q9T1g3YFouahlN1imecsboVtRs8Zg11qOICVI6AYAVgvbV-KKfDj75pS_V4xJTS5uV9Ez-jWqjomm4bISmYQzaYKPMeCgluCmnEoBU1sp6qRyKWorRbFW5VKy5v2z-9pPaP8p_raQgY9nAHPGO4dBRZMPZ9C6gCYp691_7P8AcjSeWQ</recordid><startdate>20111120</startdate><enddate>20111120</enddate><creator>Lappé, Jason M.</creator><creator>Horne, Benjamin D.</creator><creator>Shah, Svati H.</creator><creator>May, Heidi T.</creator><creator>Muhlestein, Joseph B.</creator><creator>Lappé, Donald L.</creator><creator>Kfoury, Abdallah G.</creator><creator>Carlquist, John F.</creator><creator>Budge, Deborah</creator><creator>Alharethi, Rami</creator><creator>Bair, Tami L.</creator><creator>Kraus, William E.</creator><creator>Anderson, Jeffrey L.</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20111120</creationdate><title>Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population</title><author>Lappé, Jason M. ; Horne, Benjamin D. ; Shah, Svati H. ; May, Heidi T. ; Muhlestein, Joseph B. ; Lappé, Donald L. ; Kfoury, Abdallah G. ; Carlquist, John F. ; Budge, Deborah ; Alharethi, Rami ; Bair, Tami L. ; Kraus, William E. ; Anderson, Jeffrey L.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c352t-32861461df14bb1e5913723589fd0a27263a73506ce97d2e1881819f11053db43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2011</creationdate><topic>Aged</topic><topic>Blood Cell Count</topic><topic>Blood cells</topic><topic>C-Reactive Protein - metabolism</topic><topic>Case-Control Studies</topic><topic>CBC</topic><topic>Coronary disease</topic><topic>Coronary Disease - blood</topic><topic>Coronary Disease - mortality</topic><topic>Erythrocytes - metabolism</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Proportional Hazards Models</topic><topic>RDW</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lappé, Jason M.</creatorcontrib><creatorcontrib>Horne, Benjamin D.</creatorcontrib><creatorcontrib>Shah, Svati H.</creatorcontrib><creatorcontrib>May, Heidi T.</creatorcontrib><creatorcontrib>Muhlestein, Joseph B.</creatorcontrib><creatorcontrib>Lappé, Donald L.</creatorcontrib><creatorcontrib>Kfoury, Abdallah G.</creatorcontrib><creatorcontrib>Carlquist, John F.</creatorcontrib><creatorcontrib>Budge, Deborah</creatorcontrib><creatorcontrib>Alharethi, Rami</creatorcontrib><creatorcontrib>Bair, Tami L.</creatorcontrib><creatorcontrib>Kraus, William E.</creatorcontrib><creatorcontrib>Anderson, Jeffrey L.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Clinica chimica acta</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lappé, Jason M.</au><au>Horne, Benjamin D.</au><au>Shah, Svati H.</au><au>May, Heidi T.</au><au>Muhlestein, Joseph B.</au><au>Lappé, Donald L.</au><au>Kfoury, Abdallah G.</au><au>Carlquist, John F.</au><au>Budge, Deborah</au><au>Alharethi, Rami</au><au>Bair, Tami L.</au><au>Kraus, William E.</au><au>Anderson, Jeffrey L.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population</atitle><jtitle>Clinica chimica acta</jtitle><addtitle>Clin Chim Acta</addtitle><date>2011-11-20</date><risdate>2011</risdate><volume>412</volume><issue>23-24</issue><spage>2094</spage><epage>2099</epage><pages>2094-2099</pages><issn>0009-8981</issn><eissn>1873-3492</eissn><abstract>Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal.
In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RDW and its associations with inflammation, liver function, renal function, and body mass were assessed. A population of 449 normal (No-CAD) patients also was evaluated.
RDW predicted all-cause mortality in a step-wise manner (HR=1.37 per quintile; 95% CI=1.29, 1.46; p-trend<0.001). A significant but meaningless correlation between RDW and high-sensitivity C-reactive protein (hsCRP) was identified (r=0.181; p<0.001). With full adjustment, RDW remained significant (p-trend<0.001) and the strongest predictor of mortality among all factors included in the model. RDW also strongly predicted all-cause mortality in the normal control population (HR=1.33 per quintile, CI=1.15, 1.55; p-trend<0.001), but hsCRP did not predict mortality among normal controls.
RDW was associated with mortality in patients with CAD and may provide clinically useful prognostication. Although RDW was correlated with hsCRP, they were independent predictors of mortality. RDW has been incorporated into risk prediction tool using data from basic chemistries available at: http://intermountainhealthcare.org/IMRS.
► Red cell distribution width (RDW) is associated with mortality in CAD patients. ► The etiology of RDW elevation is unknown. ► Elevation of RDW is not due to chronic inflammation as measured by hsCRP. ► RDW is also associated with mortality in controls and is not a coronary disease-specific or heart failure-specific marker. ► Despite an unknown pathophysiology, elevated RDW is a strong predictor of mortality.</abstract><cop>Netherlands</cop><pub>Elsevier B.V</pub><pmid>21821014</pmid><doi>10.1016/j.cca.2011.07.018</doi><tpages>6</tpages></addata></record> |
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| identifier | ISSN: 0009-8981 |
| ispartof | Clinica chimica acta, 2011-11, Vol.412 (23-24), p.2094-2099 |
| issn | 0009-8981 1873-3492 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Aged Blood Cell Count Blood cells C-Reactive Protein - metabolism Case-Control Studies CBC Coronary disease Coronary Disease - blood Coronary Disease - mortality Erythrocytes - metabolism Female Humans Male Middle Aged Mortality Proportional Hazards Models RDW |
| title | Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population |
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