Red cell distribution width, C-reactive protein, the complete blood count, and mortality in patients with coronary disease and a normal comparison population

Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal. In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RD...

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Veröffentlicht in:	Clinica chimica acta 2011-11, Vol.412 (23-24), p.2094-2099
Hauptverfasser:	Lappé, Jason M., Horne, Benjamin D., Shah, Svati H., May, Heidi T., Muhlestein, Joseph B., Lappé, Donald L., Kfoury, Abdallah G., Carlquist, John F., Budge, Deborah, Alharethi, Rami, Bair, Tami L., Kraus, William E., Anderson, Jeffrey L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Blood Cell Count Blood cells C-Reactive Protein - metabolism Case-Control Studies CBC Coronary disease Coronary Disease - blood Coronary Disease - mortality Erythrocytes - metabolism Female Humans Male Middle Aged Mortality Proportional Hazards Models RDW
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Zusammenfassung:	Red cell distribution width (RDW) is associated with morbidity and mortality in coronary artery disease (CAD), but the connection of RDW with chronic inflammation is equivocal. In 1,489 patients with CAD and 8.4–15.2years of follow-up all-cause mortality and RDW were studied using Cox regression. RDW and its associations with inflammation, liver function, renal function, and body mass were assessed. A population of 449 normal (No-CAD) patients also was evaluated. RDW predicted all-cause mortality in a step-wise manner (HR=1.37 per quintile; 95% CI=1.29, 1.46; p-trend
ISSN:	0009-8981 1873-3492
DOI:	10.1016/j.cca.2011.07.018