Androgen receptor expression in primary breast cancer and its predictive and prognostic value in patients treated with neoadjuvant chemotherapy

The androgen receptor (AR) has been shown to be of potential prognostic importance in retrospective cohorts. We evaluated immunohistochemical AR expression on a tissue microarray of 673 core biopsies from primary breast cancer patients treated with neoadjuvant docetaxel/doxorubicin/cyclophosphamide...

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Veröffentlicht in:	Breast cancer research and treatment 2011-11, Vol.130 (2), p.477-487
Hauptverfasser:	Loibl, Sibylle, Müller, Berit Maria, von Minckwitz, Gunter, Schwabe, Michael, Roller, Marc, Darb-Esfahani, Silvia, Ataseven, Beyhan, du Bois, Andreas, Fissler-Eckhoff, Annette, Gerber, Bernd, Kulmer, Uwe, Alles, Jens-Uwe, Mehta, Keyur, Denkert, Carsten
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvant treatment Antineoplastic Combined Chemotherapy Protocols - therapeutic use Biological and medical sciences Biomarkers Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - metabolism Breast Neoplasms - mortality Breast Neoplasms - pathology Cancer Cancer patients Cancer research Cancer therapies Carcinoma, Ductal, Breast - drug therapy Carcinoma, Ductal, Breast - metabolism Carcinoma, Ductal, Breast - mortality Carcinoma, Ductal, Breast - pathology Carcinoma, Lobular - drug therapy Carcinoma, Lobular - metabolism Carcinoma, Lobular - mortality Carcinoma, Lobular - pathology Chemotherapy Clinical Trial Clinical Trials, Phase III as Topic Comparative analysis Cyclophosphamide - administration & dosage Disease-Free Survival Doxorubicin - administration & dosage Female Gynecology. Andrology. Obstetrics Humans Immunohistochemistry Kaplan-Meier Estimate Mammary gland diseases Medical prognosis Medical sciences Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neoadjuvant Therapy Oncology Prognosis Proportional Hazards Models Prospective Studies Randomized Controlled Trials as Topic Receptors, Androgen - metabolism Taxoids - administration & dosage Tumors
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Zusammenfassung:	The androgen receptor (AR) has been shown to be of potential prognostic importance in retrospective cohorts. We evaluated immunohistochemical AR expression on a tissue microarray of 673 core biopsies from primary breast cancer patients treated with neoadjuvant docetaxel/doxorubicin/cyclophosphamide (TAC) chemotherapy in the prospective GeparTrio phase-III trial. AR was detected in 53.2% of tumours. Lowest AR expression was detected in triple-negative breast cancers (TNBC) with 21.2%. Highest AR expression was observed in Luminal A-like tumours with 67%. In AR-positive tumours, pathological complete response (pCR) rate was 12.8% compared to 25.4% in AR-negative tumours ( P
ISSN:	0167-6806 1573-7217
DOI:	10.1007/s10549-011-1715-8