A mixture of three prebiotics does not affect vaccine specific antibody responses in healthy term infants in the first year of life

Highlights ► We studied 164 infants in a RCT who were randomized to prebiotics or placebo added to formula feeding. ► We examined their immunoglobulin-G concentrations specific to Hib and tetanus immunizations. ► Prebiotics supplementation has no effect on vaccination specific antibody levels in you...

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Veröffentlicht in:	Vaccine 2011-10, Vol.29 (44), p.7766-7772
Hauptverfasser:	Stam, Jose, van Stuijvenberg, Margriet, Garssen, Johan, Knipping, Karen, Sauer, Pieter J.J
Format:	Artikel
Sprache:	eng
Schlagworte:	Allergies Allergy and Immunology Antibodies, Bacterial - blood Antibody Formation - drug effects Applied microbiology atopic dermatitis Babies Bacterial Capsules - administration & dosage Bacterial Capsules - immunology Biological and medical sciences blood serum bottle feeding breast milk Breastfeeding & lactation children fever fructooligosaccharides Fundamental and applied biological sciences. Psychology galactooligosaccharides Haemophilus Haemophilus Vaccines - administration & dosage Haemophilus Vaccines - immunology Healthy infants Humans immune response Immune system immunoglobulins Infant Infants influenza Microbiology Non-atopic Nondigestible carbohydrates Prebiotic supplementation Prebiotics risk tetanus Tetanus Toxoid - administration & dosage Tetanus Toxoid - immunology vaccination Vaccination antibody response Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
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Beschreibung
Zusammenfassung:	Highlights ► We studied 164 infants in a RCT who were randomized to prebiotics or placebo added to formula feeding. ► We examined their immunoglobulin-G concentrations specific to Hib and tetanus immunizations. ► Prebiotics supplementation has no effect on vaccination specific antibody levels in young infants.
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2011.07.110