The regulation of TNF signalling: what a tangled web we weave
Highlights ► This review focuses on ubiquitin and the role of E3 enzymes that attach it to substrates in regulating TNF signalling. ► This review highlights the results from mice that have components of the TNF signalling complex knocked out. ► Recently described types of ubiquitin modification in T...
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Veröffentlicht in: | Current opinion in immunology 2011-10, Vol.23 (5), p.620-626 |
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Format: | Artikel |
Sprache: | eng |
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Online-Zugang: | Volltext |
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Zusammenfassung: | Highlights ► This review focuses on ubiquitin and the role of E3 enzymes that attach it to substrates in regulating TNF signalling. ► This review highlights the results from mice that have components of the TNF signalling complex knocked out. ► Recently described types of ubiquitin modification in TNF signalling such as K11- and linear ubiquitin chains are discussed. ► New models of TNF signalling based on recent research and analysis in this review are proposed. |
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ISSN: | 0952-7915 1879-0372 |
DOI: | 10.1016/j.coi.2011.08.002 |