Energetics of charge-charge interactions between residues adjacent in sequence

Energetics of charge-charge interactions between residues adjacent in sequence

Statistical analysis of the residue separation between a pair of ionizable side chains within 4 Å of each other was performed on a set of 1560 non‐homologous PDB structures. We found that the frequency of pairs of like charges (i.e., pairs consisting of acidic residues Asp and Glu or pairs consistin...

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Veröffentlicht in:Proteins, structure, function, and bioinformatics structure, function, and bioinformatics, 2011-12, Vol.79 (12), p.3494-3499
Hauptverfasser: Loladze, Vakhtang V., Makhatadze, George I.
Format: Artikel
Sprache:eng
Schlagworte:
Amino Acid Substitution
Amino Acids - chemistry
Amino Acids - metabolism
Hydrogen-Ion Concentration
ion pairs
Models, Molecular
Protein Conformation
protein electrostatics
protein stability
Protein Structure, Tertiary
Protein Subunits
Proteins - chemistry
Proteins - metabolism
Static Electricity
Thermodynamics
Ubiquitin - chemistry
Ubiquitin - metabolism
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Zusammenfassung:Statistical analysis of the residue separation between a pair of ionizable side chains within 4 Å of each other was performed on a set of 1560 non‐homologous PDB structures. We found that the frequency of pairs of like charges (i.e., pairs consisting of acidic residues Asp and Glu or pairs consisting of basic residues Arg and Lys) is two orders of magnitude lower than the pairs of oppositely charged residues (salt‐bridges). We also found that for pairs of like charges the distribution is skewed dramatically towards short residue separation (
ISSN:0887-3585
1097-0134
DOI:10.1002/prot.23132