Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers
Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were...
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| Veröffentlicht in: | Journal of applied polymer science 2009-07, Vol.113 (2), p.818-826 |
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| container_title | Journal of applied polymer science |
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| creator | Kenawy, El-Refaie Al-Deyab, Salem S Omar Shaker, Nihal El-Sadek, Baheya Mohamed Khattab, Abeer H.B |
| description | Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and ¹H-NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli, Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms. |
| doi_str_mv | 10.1002/app.29814 |
| format | Article |
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Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and ¹H-NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli, Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms.</description><identifier>ISSN: 0021-8995</identifier><identifier>ISSN: 1097-4628</identifier><identifier>EISSN: 1097-4628</identifier><identifier>DOI: 10.1002/app.29814</identifier><identifier>CODEN: JAPNAB</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>antimicrobial polymers ; Applied sciences ; Bacillus ; Bacteria ; biocide ; Biological and medical sciences ; Copolymerization ; Copolymers ; Drugs ; Escherichia coli ; Exact sciences and technology ; General pharmacology ; Medical sciences ; metronidazole ; Monomers ; Organic polymers ; Organisms ; Pharmaceutical technology. Pharmaceutical industry ; Pharmacology. Drug treatments ; Physicochemistry of polymers ; Polymers with particular properties ; Polymethyl methacrylates ; Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><ispartof>Journal of applied polymer science, 2009-07, Vol.113 (2), p.818-826</ispartof><rights>Copyright © 2009 Wiley Periodicals, Inc.</rights><rights>2015 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5614-ac0df187e800924cf1a64654c349aa05a4f9c1bb629698346deb2404fb9c9f713</citedby><cites>FETCH-LOGICAL-c5614-ac0df187e800924cf1a64654c349aa05a4f9c1bb629698346deb2404fb9c9f713</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fapp.29814$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fapp.29814$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21526883$$DView record in Pascal Francis$$Hfree_for_read</backlink></links><search><creatorcontrib>Kenawy, El-Refaie</creatorcontrib><creatorcontrib>Al-Deyab, Salem S</creatorcontrib><creatorcontrib>Omar Shaker, Nihal</creatorcontrib><creatorcontrib>El-Sadek, Baheya Mohamed</creatorcontrib><creatorcontrib>Khattab, Abeer H.B</creatorcontrib><title>Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers</title><title>Journal of applied polymer science</title><addtitle>J. Appl. Polym. Sci</addtitle><description>Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and ¹H-NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli, Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms.</description><subject>antimicrobial polymers</subject><subject>Applied sciences</subject><subject>Bacillus</subject><subject>Bacteria</subject><subject>biocide</subject><subject>Biological and medical sciences</subject><subject>Copolymerization</subject><subject>Copolymers</subject><subject>Drugs</subject><subject>Escherichia coli</subject><subject>Exact sciences and technology</subject><subject>General pharmacology</subject><subject>Medical sciences</subject><subject>metronidazole</subject><subject>Monomers</subject><subject>Organic polymers</subject><subject>Organisms</subject><subject>Pharmaceutical technology. Pharmaceutical industry</subject><subject>Pharmacology. Drug treatments</subject><subject>Physicochemistry of polymers</subject><subject>Polymers with particular properties</subject><subject>Polymethyl methacrylates</subject><subject>Preparation, kinetics, thermodynamics, mechanism and catalysts</subject><issn>0021-8995</issn><issn>1097-4628</issn><issn>1097-4628</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2009</creationdate><recordtype>article</recordtype><recordid>eNqFkUtvFDEQhC0EEsvCgV_AXHgdJnHbHo99TCIISCsILNFKXKxerx0M88KeAMOvx2SW3EgOlmX1V6UuFyGPgR4ApewQh-GAaQXiDlkA1XUpJFN3ySLPoFRaV_fJg5S-UgpQUbkgm_XUjV9cCqnAbpfPGNpgY78N2BRox_AjjFPR-6J1Y-y7sMPffeMK23cjhi50F8XQN1Pr4pXc9vtXekjueWySe7S_l-T89atPJ2_K1fvTtydHq9JWEkSJlu48qNopSjUT1gNKISthudCItELhtYXtVjItteJC7tyWCSr8Vlvta-BL8nz2HWL__dKl0bQhWdc02Ln-MhlNuRS1FPpWUmnJQDEhM_nsRpILUVMm4VaQ0UrL_M0ZfHEjCDJHYZrniEvyckZzCSlF580QQ4txMkDN34pNrthcVZzZp3tbTBYbH7GzIV0LGFRMKsUzdzhzP0Pjpv8bmqOzs3_O5awIaXS_rhUYvxlZ87oym3en5vjjqlrD5w9mk_knM--xN3gR8xbna0aBU5CMM2D8DykZzPg</recordid><startdate>20090715</startdate><enddate>20090715</enddate><creator>Kenawy, El-Refaie</creator><creator>Al-Deyab, Salem S</creator><creator>Omar Shaker, Nihal</creator><creator>El-Sadek, Baheya Mohamed</creator><creator>Khattab, Abeer H.B</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley</general><scope>FBQ</scope><scope>BSCLL</scope><scope>IQODW</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>JG9</scope><scope>7QL</scope><scope>7T7</scope><scope>C1K</scope><scope>FR3</scope><scope>M7N</scope><scope>P64</scope></search><sort><creationdate>20090715</creationdate><title>Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers</title><author>Kenawy, El-Refaie ; Al-Deyab, Salem S ; Omar Shaker, Nihal ; El-Sadek, Baheya Mohamed ; Khattab, Abeer H.B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5614-ac0df187e800924cf1a64654c349aa05a4f9c1bb629698346deb2404fb9c9f713</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2009</creationdate><topic>antimicrobial polymers</topic><topic>Applied sciences</topic><topic>Bacillus</topic><topic>Bacteria</topic><topic>biocide</topic><topic>Biological and medical sciences</topic><topic>Copolymerization</topic><topic>Copolymers</topic><topic>Drugs</topic><topic>Escherichia coli</topic><topic>Exact sciences and technology</topic><topic>General pharmacology</topic><topic>Medical sciences</topic><topic>metronidazole</topic><topic>Monomers</topic><topic>Organic polymers</topic><topic>Organisms</topic><topic>Pharmaceutical technology. Pharmaceutical industry</topic><topic>Pharmacology. Drug treatments</topic><topic>Physicochemistry of polymers</topic><topic>Polymers with particular properties</topic><topic>Polymethyl methacrylates</topic><topic>Preparation, kinetics, thermodynamics, mechanism and catalysts</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kenawy, El-Refaie</creatorcontrib><creatorcontrib>Al-Deyab, Salem S</creatorcontrib><creatorcontrib>Omar Shaker, Nihal</creatorcontrib><creatorcontrib>El-Sadek, Baheya Mohamed</creatorcontrib><creatorcontrib>Khattab, Abeer H.B</creatorcontrib><collection>AGRIS</collection><collection>Istex</collection><collection>Pascal-Francis</collection><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>Materials Research Database</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><jtitle>Journal of applied polymer science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kenawy, El-Refaie</au><au>Al-Deyab, Salem S</au><au>Omar Shaker, Nihal</au><au>El-Sadek, Baheya Mohamed</au><au>Khattab, Abeer H.B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers</atitle><jtitle>Journal of applied polymer science</jtitle><addtitle>J. Appl. Polym. Sci</addtitle><date>2009-07-15</date><risdate>2009</risdate><volume>113</volume><issue>2</issue><spage>818</spage><epage>826</epage><pages>818-826</pages><issn>0021-8995</issn><issn>1097-4628</issn><eissn>1097-4628</eissn><coden>JAPNAB</coden><abstract>Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and ¹H-NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli, Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><doi>10.1002/app.29814</doi><tpages>9</tpages></addata></record> |
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| source | Wiley Online Library Journals Frontfile Complete |
| subjects | antimicrobial polymers Applied sciences Bacillus Bacteria biocide Biological and medical sciences Copolymerization Copolymers Drugs Escherichia coli Exact sciences and technology General pharmacology Medical sciences metronidazole Monomers Organic polymers Organisms Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular properties Polymethyl methacrylates Preparation, kinetics, thermodynamics, mechanism and catalysts |
| title | Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers |
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