Synthesis and antimicrobial activity of metronidazole containing polymer and copolymers

Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were...

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Veröffentlicht in:	Journal of applied polymer science 2009-07, Vol.113 (2), p.818-826
Hauptverfasser:	Kenawy, El-Refaie, Al-Deyab, Salem S, Omar Shaker, Nihal, El-Sadek, Baheya Mohamed, Khattab, Abeer H.B
Format:	Artikel
Sprache:	eng
Schlagworte:	antimicrobial polymers Applied sciences Bacillus Bacteria biocide Biological and medical sciences Copolymerization Copolymers Drugs Escherichia coli Exact sciences and technology General pharmacology Medical sciences metronidazole Monomers Organic polymers Organisms Pharmaceutical technology. Pharmaceutical industry Pharmacology. Drug treatments Physicochemistry of polymers Polymers with particular properties Polymethyl methacrylates Preparation, kinetics, thermodynamics, mechanism and catalysts
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Zusammenfassung:	Homopolymer and copolymers containing metronidazole (MTZ) drug were synthesized. Acryloyl chloride was reacted with MTZ (drug) to produce monomer containing MTZ, and then the monomer was copolymerized with various amounts of methyl methacrylate. The produced monomer, homopolymer, and copolymers were characterized by elemental analysis, IR, and ¹H-NMR. The antimicrobial activities of the synthesized polymers were tested against Kelpsilic as fungal organisms, and Escherichia coli, Bacillus subitilus, and Pesudomonus areuginosa as bacteria organisms.
ISSN:	0021-8995 1097-4628 1097-4628
DOI:	10.1002/app.29814