Negative effects of serum p,p′-DDE on sperm parameters and modification by genetic polymorphisms

Effects of ambient exposure to DDT and its metabolites (DDE-DDT) on human sperm parameters and the role of genetic polymorphisms in modifying the association were investigated. Demographics, medical history data, blood and semen samples were obtained from the first 336 male partners of couples prese...

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Veröffentlicht in:	Environmental research 2009-05, Vol.109 (4), p.457-464
Hauptverfasser:	Messaros, Bridget M., Rossano, Mary G., Liu, Guanghui, Diamond, Michael P., Friderici, Karen, Nummy-Jernigan, Katherine, Daly, Douglas, Puscheck, Elizabeth, Paneth, Nigel, Wirth, Julia J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adolescent Adult Biological and medical sciences Case-Control Studies CYP1A1 Cytochrome P-450 CYP1A1 - genetics DDT - blood DDT - toxicity Dichlorodiphenyl Dichloroethylene - toxicity DNA - chemistry Environmental Exposure Gene Frequency Genetic polymorphisms Genotype Glutathione Transferase - genetics GSTM1 GSTT1 Human exposure Humans Infertility, Male - etiology Infertility, Male - genetics Insecticides - blood Insecticides - toxicity Male Medical sciences Middle Aged Odds Ratio p,p′-DDE Pesticides, fertilizers and other agrochemicals toxicology Polymorphism, Genetic Semen - cytology Semen - drug effects Sperm Sperm Count Sperm Motility - drug effects Sperm Motility - physiology Spermatozoa - drug effects Spermatozoa - enzymology Toxicology Young Adult
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Zusammenfassung:	Effects of ambient exposure to DDT and its metabolites (DDE-DDT) on human sperm parameters and the role of genetic polymorphisms in modifying the association were investigated. Demographics, medical history data, blood and semen samples were obtained from the first 336 male partners of couples presenting to 2 infertility clinics. Serum was analyzed for organochlorines (OC) and DNA for polymorphisms in GSTM1, GSTT1, GSTP1 and CYP1A1. Men with each sperm parameter considered low by WHO criteria (concentration
ISSN:	0013-9351 1096-0953
DOI:	10.1016/j.envres.2009.02.009