Febrile infection–related epilepsy syndrome (FIRES): Does duration of anesthesia affect outcome?

Summary We conducted a retrospective multicenter study on children who had been included in eight studies published between November 2001 and July 2010 to explore the correlations between burst‐suppression coma (BSC) with outcome in febrile infection‐related epilepsy syndrome (FIRES). The 77 enrolle...

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Veröffentlicht in:	Epilepsia (Copenhagen) 2011-10, Vol.52 (s8), p.28-30
Hauptverfasser:	Kramer, Uri, Chi, Ching‐Shiang, Lin, Kuang‐Lin, Specchio, Nicola, Sahin, Mustafa, Olson, Heather, Kluger, Gerhard, van Baalen, Andreas
Format:	Artikel
Sprache:	eng
Schlagworte:	Anesthesia - adverse effects Anticonvulsants. Antiepileptics. Antiparkinson agents Biological and medical sciences Child Child, Preschool Children Cognition Disorders - etiology Coma - chemically induced Coma - physiopathology Encephalitis - complications Epilepsy Female Follow-Up Studies Headache. Facial pains. Syncopes. Epilepsia. Intracranial hypertension. Brain oedema. Cerebral palsy Humans Male Medical sciences Nervous system (semeiology, syndromes) Neurology Neuropharmacology Pharmacology. Drug treatments Refractory Retrospective Studies Seizures, Febrile - etiology Seizures, Febrile - therapy Status epilepticus Time Factors Treatment Outcome
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Zusammenfassung:	Summary We conducted a retrospective multicenter study on children who had been included in eight studies published between November 2001 and July 2010 to explore the correlations between burst‐suppression coma (BSC) with outcome in febrile infection‐related epilepsy syndrome (FIRES). The 77 enrolled patients presented with prolonged refractory status epilepticus. BSC was induced in 46 patients. Cognitive levels at follow‐up were significantly associated with duration of a BSC (p = 0.005). The outcome of FIRES is poor. Treatment by inducing a prolonged BSC was associated with a worse cognitive outcome.
ISSN:	0013-9580 1528-1167
DOI:	10.1111/j.1528-1167.2011.03230.x