Biogenesis of 2-agmatinylcytidine catalyzed by the dual protein and RNA kinase TiaS

Archaea use a tRNA Ile with agmatine conjugated at the C34 position to decode the AUA codon. The enzyme that catalyzes this reaction, TiaS, has been previously identified, and it is now shown that it uses a novel kinase domain to hydrolyze ATP into AMP and pyrophosphate before phosphorylating itself...

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